Epithelial–mesenchymal transition (EMT) is a program wherein epithelial cells lose their
junctions and polarity while acquiring mesenchymal properties and invasive ability …

Background Increasing evidences indicate that circular RNAs exert critical function in
regulating bladder cancer progression. However, the expressive patterns and roles of …

Gastric cancer is a deadly disease and remains the third leading cause of cancer-related
death worldwide. The 5-year overall survival rate of patients with early-stage localized …

Background Hypoxia, a fundamental characteristic of glioma, is considered to promote tumor
malignancy by inducing process of epithelial mesenchymal transition (EMT). Ferritin Light …

Background Nucleotide metabolism is a critical pathway that generates purine and
pyrimidine molecules for DNA replication, RNA synthesis, and cellular bioenergetics …

Abstract Background DNA N6-methyldeoxyadenosine (6mA) is rarely present in mammalian
cells and its nuclear role remains elusive. Results Here we show that hypoxia induces …

A common feature of many solid tumors is low oxygen conditions due to inadequate blood
supply. Hypoxia induces hypoxia inducible factor (HIF) stabilization and downstream …

The tumor microenvironment (TME) consists of various components including cancer cells,
tumor vessels, cancer‐associated fibroblasts (CAFs), and inflammatory cells. These …

Indolent (lepidic) and aggressive (micropapillary, solid, and poorly differentiated acinar)
histologic subtypes often coexist within a tumor tissue of lung adenocarcinoma (LUAD), but …

Cancer-associated fibroblasts (CAFs) have been shown to play a strong role in colorectal
cancer metastasis, yet the underlying mechanism remains to be fully elucidated. Using CRC …