The epithelial-to-mesenchymal transition (EMT), an embryonic program relaunched during
wound healing and in pathological conditions such as fibrosis and cancer, continues to gain …

Cell identity is largely determined by its transcriptional profile. In tumour, deregulation of
transcription factor expression and/or activity enables cancer cell to acquire a stem-like state …

Lymph node metastasis is a major factor that affects prognosis in patients with lung
adenocarcinoma (LUAD). In some cases, lymph node metastasis has already occurred …

Epithelial to mesenchymal transition (EMT) is a process where cancer cells lose their
epithelial features, the cytoskeletal architecture is re-organized, the cell shape changes and …

Background: Immune checkpoint inhibitors (ICIs), such as programmed cell death protein 1
(PD-1)/programmed death-ligand 1 (PD-L1), have been widely applied in clinical and …

Radiotherapy causes DNA damage by direct ionization and indirect generation of reactive
oxygen species (ROS) thereby destroying cancer cells. However, ionizing radiation (IR) …

Tumor progression is associated with dedifferentiated histopathologies concomitant with
cancer cell survival within a changing, and often hostile, tumor microenvironment. These …

Cancer is a complex expression of an altered state of cellular differentiation associated with
severe clinical repercussions. The effort to characterize this pathological entity to understand …

Dysregulation of transcription factors is one of the common problems in the pathogenesis of
human cancer. Among them, SOX9 is one of the critical transcription factors involved in …

Aquaporin (AQP) water channels are pivotal to renal water handling and therefore in the
regulation of body water homeostasis. However, beyond the kidney, AQPs facilitate water …