Mammalian eggs (oocytes) are formed during fetal life and establish associations with
somatic cells to form primordial follicles that create a store of germ cells (the primordial pool) …

Meiotic progression in mammalian preovulatory follicles is controlled by the granulosa cells
around the oocyte. Cyclic GMP (cGMP) generated in the granulosa cells diffuses through …

Mammalian oocytes are arrested in meiotic prophase by an inhibitory signal from the
surrounding somatic cells in the ovarian follicle. In response to luteinizing hormone (LH) …

The G protein-coupled receptors 3, 6, and 12 (GPR3, GPR6, and GPR12) comprise a family
of closely related orphan receptors with no confirmed endogenous ligands. These receptors …

Luteinizing hormone (LH) acts on ovarian follicles to reinitiate meiosis in prophase-arrested
mammalian oocytes, and this has been proposed to occur by interruption of a meioisis …

In vitro maturation (IVM) of human immature oocytes has been shown to be a viable option
for patients at risk of ovarian hyperstimulation syndrome (OHSS), those seeking urgent …

In vitro maturation (IVM) of human immature oocytes has been offered to women who are at
risk of developing ovarian hyperstimulation syndrome (OHSS) caused by gonadotropin …

Mammalian oocytes are arrested at prophase I until puberty when luteinizing hormone (LH)
induces resumption of meiosis of follicle-enclosed oocytes. Resumption of meiosis is tightly …

Mammalian oocytes are arrested at the prophase of the first meiotic division for months and
even years, depending on species. Meiotic resumption of fully grown oocytes requires …

Mammalian oocytes spend the majority of their lives in a dormant state, residing in
primordial follicles. This arrest, most analogous to the G2 stage of the mitotic cell cycle …