Kinins are generated within inflammatory tissue microenvironments, where they exert
diverse functions, including cell proliferation, leukocyte activation, cell migration, endothelial …

In recent years, ACE Inhibitors (ACEIs) and Angiotensin II receptor antagonists (also known
as AT1 receptor antagonists (AT1-RAs), angiotensin receptor blockers (ARBs), or Sartans) …

Endogenous kinins are important vasoactive peptides whose effects are mediated by two G-
Protein-coupled receptors (R), named B2R (constitutive) and B1R (inducible). They are …

Hypertension is characterized by an imbalance between the renin–angiotensin system
(RAS) and the kallikrein–kinin system (KKS). Angiotensin-converting enzyme inhibitors …

Phospholipase A 2 is a known aggravator of inflammation and deteriorates neurological
outcomes after traumatic brain injury (TBI), however the exact inflammatory mechanisms …

Abstract During ischemia/reperfusion (IR), increased activation of angiotensin AT 1
receptors recruits NADPH oxidase 2 (NOX2) which contributes to oxidative stress. It is …

Aim The pathophysiology of periodontal diseases involves aspects of immunity and bone
remodelling. Considering the role of the kinin B1 receptor (Bdkrb1) in inflammation and …

Background: Kinin B 1 receptor (B 1 R) intervenes in a positive feedback loop to amplify and
perpetuate the vascular oxidative stress in glucose-fed rats, a model of insulin resistance …

Abstract Angiotensin II (Ang II), a mitogen-activated peptide, exerts numerous effects on the
cardiovascular system including the regulation of blood pressure. The current study focused …

Background Kinins are mediators of pain and inflammation. Their role in thermoregulation is,
however, unknown despite the fact the B1 receptor (B1R) was found implicated in …