Mitochondrial oxidative phosphorylation in viral infections

N Purandare, E Ghosalkar, LI Grossman, S Aras - Viruses, 2023 - mdpi.com
Mitochondria have been identified as the “powerhouse” of the cell, generating the cellular
energy, ATP, for almost seven decades. Research over time has uncovered a multifaceted …

[HTML][HTML] Recurrent congenital cytomegalovirus infection in a sequential pregnancy with severe sequelae, and a possible association with prophylactic valacyclovir …

T Brosh-Nissimov, N Benshalom-Tirosh… - International Journal of …, 2022 - Elsevier
Recurrent congenital cytomegalovirus infections in consecutive pregnancies are rarely
reported. Due to the risk of fetal infection from preconception maternal infection, a 6-month …

Profiling human cytomegalovirus-specific T cell responses reveals novel immunogenic open reading frames

R Dhanwani, SK Dhanda, J Pham, GP Williams… - Journal of …, 2021 - Am Soc Microbiol
Despite the prevalence and medical significance of human cytomegalovirus (HCMV)
infections, a systematic analysis of the targets of T cell recognition in humans that spans the …

The aryl hydrocarbon receptor facilitates the human cytomegalovirus-mediated G1/S block to cell cycle progression

P Naseri-Nosar, MT Nogalski… - Proceedings of the …, 2021 - National Acad Sciences
The tryptophan metabolite, kynurenine, is known to be produced at elevated levels within
human cytomegalovirus (HCMV)-infected fibroblasts. Kynurenine is an endogenous aryl …

Horizontal transmission of cytomegalovirus in a rhesus model despite high-level, vaccine-elicited neutralizing antibody and T-cell responses

J Li, S Wellnitz, XS Chi, Y Yue… - The Journal of …, 2022 - academic.oup.com
The development of a vaccine to prevent congenital human cytomegalovirus (HCMV)
disease is a public health priority. We tested rhesus CMV (RhCMV) prototypes of HCMV …

Stabilization of the human cytomegalovirus UL136p33 reactivation determinant overcomes the requirement for UL135 for replication in hematopoietic cells

MA Moy, D Collins-McMillen, L Crawford… - Journal of …, 2023 - Am Soc Microbiol
Human cytomegalovirus (HCMV) is a beta herpesvirus that persists indefinitely in the human
host through a latent infection. The polycistronic UL133–UL138 gene locus of HCMV …

Expanding the known functional repertoire of the human cytomegalovirus pp71 protein

RF Kalejta, ER Albright - Frontiers in cellular and infection …, 2020 - frontiersin.org
The human cytomegalovirus pp71 protein is packaged within the tegument of infectious
virions and performs multiple functions in host cells to prime them for productive, lytic …

Genetic variability of human cytomegalovirus clinical isolates correlates with altered expression of natural killer cell-activating ligands and IFN-γ

G Galitska, A Coscia, D Forni, L Steinbrueck… - Frontiers in …, 2021 - frontiersin.org
Human cytomegalovirus (HCMV) infection often leads to systemic disease in
immunodeficient patients and congenitally infected children. Despite its clinical significance …

Human cytomegalovirus-encoded MicroRNAs: A master regulator of latent infection

AE Abdalla, MO Mahjoob, KOA Abosalif, H Ejaz… - Infection, Genetics and …, 2020 - Elsevier
Human cytomegalovirus (HCMV) can modulate the host cell microenvironment to cause
latent infection and is therefore considered a major health concern in immunocompromised …

Production strategies for pentamer-positive subviral dense bodies as a safe human cytomegalovirus vaccine

P Gogesch, I Penner, S Krauter, N Büscher, L Grode… - Vaccines, 2019 - mdpi.com
Infections with the human cytomegalovirus (HCMV) are associated with severe clinical
manifestations in children following prenatal transmission and after viral reactivation in …