Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response

YY Wu, TK Sun, MS Chen, M Munir… - Frontiers in Cellular and …, 2023 - frontiersin.org
Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer
therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis …

Oncolytic virotherapy in cancer treatment: challenges and optimization prospects

L Chen, M Zuo, Q Zhou, Y Wang - Frontiers in Immunology, 2023 - frontiersin.org
Oncolytic viruses (OVs) are emerging cancer therapeutics that offer a multifaceted
therapeutic platform for the benefits of replicating and lysing tumor cells, being engineered …

Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, sensitizes cancer cells to VSVΔ51 oncolytic virotherapy

B Wong, A Bergeron, G Maznyi, K Ng, A Jirovec… - Molecular Therapy, 2023 - cell.com
The clinical efficacy of VSVΔ51 oncolytic virotherapy has been limited by tumor resistance to
viral infection, so strategies to transiently repress antiviral defenses are warranted …

Integrating innate and adaptive immunity in oncolytic virus therapy

K DePeaux, GM Delgoffe - Trends in Cancer, 2023 - cell.com
Oncolytic viruses (OVs), viruses engineered to lyse tumor cells, work hand in hand with the
immune response. While for decades the field isolated lytic capability and viral spread to …

Targeting the epigenome to reinvigorate T cells for cancer immunotherapy

D Xiong, L Zhang, ZJ Sun - Military Medical Research, 2023 - Springer
Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the
field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of …

Development and application of oncolytic viruses as the nemesis of tumor cells

X Zhu, C Fan, Z Xiong, M Chen, Z Li, T Tao… - Frontiers in …, 2023 - frontiersin.org
Viruses and tumors are two pathologies that negatively impact human health, but what
occurs when a virus encounters a tumor? A global consensus among cancer patients …

Epigenetic regulation of pyroptosis in cancer: molecular pathogenesis and targeting strategies

RN Zhang, ZQ Jing, L Zhang, ZJ Sun - Cancer Letters, 2023 - Elsevier
Immune checkpoint blockade therapy has revolutionized the field of cancer treatment,
leading to durable responses in patients with advanced and metastatic cancers where …

[HTML][HTML] Immunotherapeutic approaches in Hepatocellular carcinoma: Building blocks of hope in near future

N Minaei, R Ramezankhani, A Tamimi, A Piryaei… - European Journal of …, 2023 - Elsevier
Hepatocellular carcinoma (HCC) is the most common type of primary hepatic cancer and is
among the major causes of mortality due to cancer. Due to the lack of efficient conventional …

Microbiota in cancer: molecular mechanisms and therapeutic interventions

Z Chen, D Guan, Z Wang, X Li, S Dong, J Huang… - MedComm, 2023 - Wiley Online Library
The diverse bacterial populations within the symbiotic microbiota play a pivotal role in both
health and disease. Microbiota modulates critical aspects of tumor biology including cell …

Targeting the stimulator of interferon genes (STING) in breast cancer

M Ying-Rui, B Bu-Fan, L Deng, S Rong… - Frontiers in …, 2023 - frontiersin.org
Breast cancer has a high occurrence rate globally and its treatment has demonstrated
clinical efficacy with the use of systemic chemotherapy and immune checkpoint blockade …