Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody

D Frescas, CM Roux, S Aygun-Sunar… - Proceedings of the …, 2017 - National Acad Sciences
Studying the phenomenon of cellular senescence has been hindered by the lack of
senescence-specific markers. As such, detection of proteins informally associated with …

Single-cell transcriptomic atlas of different human cardiac arteries identifies cell types associated with vascular physiology

Z Hu, W Liu, X Hua, X Chen, Y Chang… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Although cellular heterogeneity within arterial walls has been explored in mice
and nonhuman primates, the cellular composition of human arterial walls remains unclear …

Lipoprotein (a) and its role in inflammation, atherosclerosis and malignancies

E Orsó, G Schmitz - Clinical research in cardiology supplements, 2017 - Springer
Abstract Lipoprotein (a)(Lp (a)) is a modified low-density lipoprotein (LDL) particle with an
additional specific apolipoprotein (a), covalently attached to apolipoprotein B‑100 of LDL by …

The role of T and B cells in human atherosclerosis and atherothrombosis

E Ammirati, F Moroni, M Magnoni… - Clinical & Experimental …, 2015 - academic.oup.com
Far from being merely a passive cholesterol accumulation within the arterial wall, the
development of atherosclerosis is currently known to imply both inflammation and immune …

[HTML][HTML] Human B-1 cells and B-1 cell antibodies change with advancing age

N Rodriguez-Zhurbenko, TD Quach… - Frontiers in …, 2019 - frontiersin.org
Age-related deficits in the immune system have been associated with an increased
incidence of infections, autoimmune diseases, and cancer. Human B cell populations …

[HTML][HTML] The neutrophil-to-lymphocyte ratio is an important indicator predicting in-hospital death in AMI patients

Z Ji, G Liu, J Guo, R Zhang, Y Su, A Carvalho… - Frontiers in …, 2021 - frontiersin.org
Objective: To explore the role of neutrophil-to-lymphocyte ratio (NLR) in predicting the short-
term prognosis of NSTEMI and STEMI. Methods: This study was a single-center …

Type-I interferons in atherosclerosis

HJ Chen, SW Tas, MPJ De Winther - Journal of Experimental Medicine, 2019 - rupress.org
The contribution of dyslipidemia and inflammation in atherosclerosis is well established.
Along with effective lipid-lowering treatments, the recent success of clinical trials with anti …

Vaccination strategies and immune modulation of atherosclerosis

J Nilsson, GK Hansson - Circulation Research, 2020 - Am Heart Assoc
Adaptive as well as innate immune responses contribute to the development of
atherosclerosis. Studies performed in experimental animals have revealed that some of …

Macrophages and dendritic cells: partners in atherogenesis

MI Cybulsky, C Cheong, CS Robbins - Circulation research, 2016 - Am Heart Assoc
Atherosclerosis is a complex chronic disease. The accumulation of myeloid cells in the
arterial intima, including macrophages and dendritic cells (DCs), is a feature of early stages …

Unbiased plasma proteomics discovery of biomarkers for improved detection of subclinical atherosclerosis

E Nunez, V Fuster, M Gómez-Serrano… - …, 2022 - thelancet.com
Background Imaging of subclinical atherosclerosis improves cardiovascular risk prediction
on top of traditional risk factors. However, cardiovascular imaging is not universally …