Fcγ receptors (FcγRs) classically modulate intracellular signaling on binding of the Fc region
of IgG in immune response cells. How FcγR and their ligands affect cardiovascular health …

Rationale: Deficiency of secreted IgM (sIgM−/−) accelerates atherosclerosis in Ldlr−/− mice.
Several atheroprotective effects of increased levels of IgM antibodies have been suggested …

Background Macrophages and T lymphocytes in the perivascular adipose tissue (Pv AT)
were previously linked to coronary artery disease. However, the role of these cells and B …

Objective—The roles of microRNAs (miRNAs) in coronary heart disease (CHD) have not
been well characterized. This study sought to systematically characterize the complex …

It is well established that post-stroke inflammation contributes to neurovascular injury, blood–
brain barrier disruption, and poor functional recovery in both animal and clinical studies …

An improper balance between the production and elimination of intracellular reactive
oxygen species causes increased oxidative stress. Consequently, DNA, RNA, proteins, and …

B cells are a core element of the pathophysiology of atherosclerotic cardiovascular disease
(ASCVD). Multiple experimental and epidemiological studies have revealed both protective …

Objective—Previous smaller studies have indicated inverse associations between
autoantibodies to oxidized low-density lipoprotein epitopes, and cardiovascular disease …

BACKGROUND: Carotid atherosclerosis is a chronic inflammatory disorder and is
responsible for the vast majority of ischemic strokes. Inappropriate innate and adaptive …

Rheumatoid arthritis (RA), one of the most common of the chronic inflammatory autoimmune
diseases (CIADs), is recognized as an independent cardiovascular risk factor. Traditional …