Abstract Crick's Central Dogma has been a foundational aspect of 20th century biology,
describing an implicit relationship governing the flow of information in biological systems in …

Metabolomics uses advanced analytical chemistry methods to analyze metabolites in
biological samples. The most intensively studied samples are blood and its liquid …

Mass spectrometry-based proteomics is a sophisticated identification tool specializing in
portraying protein dynamics at a molecular level. Proteomics provides biologists with a …

Parkinson's disease (PD) is a widespread neurodegenerative disorder, whose complex
aetiology remains under construction. While rare variants have been associated with the …

The adsorbed vaccine SARS-CoV-2 (inactivated) produced by Sinovac (SV) was the first
vaccine against COVID-19 to be used in Brazil. To understand the metabolic effects of SV in …

Although a plethora of DNA modifications have been extensively investigated in the last
decade, recent breakthroughs in molecular biology, including high throughput sequencing …

Traditionally ignored in comparison with the energy flow, the interest on the information flow
and in general on the informational perspective is nowadays manifest in biological fields …

Brazil has the second-highest COVID-19 death rate worldwide, and Rio de Janeiro is among
the states with the highest rate in the country. Although vaccine coverage has been …

Background Missing data is a common challenge in mass spectrometry-based
metabolomics, which can lead to biased and incomplete analyses. The integration of whole …

MicroRNAs (miRNAs) are synthesized through a canonical pathway and play a role in
human diseases, such as cancers and cardiovascular, neurodegenerative, psychiatric, and …