Targeting Notch in oncology: the path forward
S Majumder, JS Crabtree, TE Golde… - Nature Reviews Drug …, 2021 - nature.com
Notch signalling is involved in many aspects of cancer biology, including angiogenesis,
tumour immunity and the maintenance of cancer stem-like cells. In addition, Notch can …
tumour immunity and the maintenance of cancer stem-like cells. In addition, Notch can …
[HTML][HTML] Melatonin in cancer treatment: current knowledge and future opportunities
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …
experimental studies have documented that melatonin could inhibit different types of cancer …
Melatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas
Melatonin is an ancient antioxidant. After its initial development in bacteria, it has been
retained throughout evolution such that it may be or may have been present in every species …
retained throughout evolution such that it may be or may have been present in every species …
[HTML][HTML] Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop
F Chen, G Jiang, H Liu, Z Li, Y Pei, H Wang, H Pan… - Bone research, 2020 - nature.com
The inflammatory response is induced by the overexpression of inflammatory cytokines,
mainly interleukin (IL)-1β, and is one of the main causes of intervertebral disc degeneration …
mainly interleukin (IL)-1β, and is one of the main causes of intervertebral disc degeneration …
[HTML][HTML] Melatonin: a cutaneous perspective on its production, metabolism, and functions
AT Slominski, R Hardeland, MA Zmijewski… - Journal of Investigative …, 2018 - Elsevier
Melatonin, an evolutionarily ancient derivative of serotonin with hormonal properties, is the
main neuroendocrine secretory product of the pineal gland. Although melatonin is best …
main neuroendocrine secretory product of the pineal gland. Although melatonin is best …
Melatonin: A mitochondrial resident with a diverse skill set
Melatonin is an ancient molecule that originated in bacteria. When these prokaryotes were
phagocytized by early eukaryotes, they eventually developed into mitochondria and …
phagocytized by early eukaryotes, they eventually developed into mitochondria and …
[HTML][HTML] Importance of melatonin in assisted reproductive technology and ovarian aging
H Tamura, M Jozaki, M Tanabe, Y Shirafuta… - International journal of …, 2020 - mdpi.com
Melatonin is probably produced in all cells but is only secreted by the pineal gland. The
pineal secretion of melatonin is determined by the light–dark cycle, and it is only released at …
pineal secretion of melatonin is determined by the light–dark cycle, and it is only released at …
[HTML][HTML] Roles of melatonin in the field of reproductive medicine
W Yong, H Ma, M Na, T Gao, Y Zhang, L Hao… - Biomedicine & …, 2021 - Elsevier
Melatonin, mostly released by the pineal gland, is a circadian rhythm-regulated and
multifunctional hormone. Great advances in melatonin research have been made, including …
multifunctional hormone. Great advances in melatonin research have been made, including …
[HTML][HTML] Membrane melatonin receptors activated cell signaling in physiology and disease
G Nikolaev, R Robeva, R Konakchieva - International journal of molecular …, 2021 - mdpi.com
The pineal hormone melatonin has attracted great scientific interest since its discovery in
1958. Despite the enormous number of basic and clinical studies the exact role of melatonin …
1958. Despite the enormous number of basic and clinical studies the exact role of melatonin …
AMPK/PGC1α activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis
D Liu, Z Ma, S Di, Y Yang, J Yang, L Xu… - Free Radical Biology …, 2018 - Elsevier
Doxorubicin (DOX) is a highly effective anticancer anthracycline drug, but its side effects at
the level of the heart has limited its widespread clinical application. Melatonin is a …
the level of the heart has limited its widespread clinical application. Melatonin is a …