Research involving nonhuman primates (NHPs) has played a vital role in many of the
medical and scientific advances of the past century. NHPs are used because of their …

People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …

The lack of a primate model that utilizes HIV-1 as the challenge virus is an impediment to
AIDS research; existing models generally employ simian viruses that are divergent from HIV …

How botulinum neurotoxins (BoNTs) cross the host intestinal epithelial barrier in foodborne
botulism is poorly understood. Here, we present the crystal structure of a clostridial …

Rhesus macaques are an important animal model for the study of human disease and the
development of vaccines against HIV and AIDS. HIV vaccines have been benchmarked in …

Highlights•HIV the causative agent of AIDS has an extremely limited tropism and does not
replicate in mice, rats or non-human primates.•Humanized mouse models contain different …

In 2004, the first report of TRIM5α as a cellular antiretroviral factor triggered intense interest
among virologists, particularly because some primate orthologs of TRIM5α have activity …

Non-human primates (NHPs) are phylogenetically close to humans, with many similarities in
terms of physiology, anatomy, immunology, as well as neurology, all of which make them …

HIV infection and drug use intersect epidemiologically, and their combination can result in
complex effects on brain and behavior. The extent to which drugs affect the health of …

HIV-1 infection causes injury to the central nervous system (CNS) and is often associated
with neurocognitive disorders. One model for brain damage seen in AIDS patients is the …