Cancer cells alter metabolic processes to sustain their characteristic uncontrolled growth
and proliferation. These metabolic alterations include (1) a shift from oxidative …

Monoclonal antibodies targeting programmed cell death 1/programmed cell death ligand 1
(PD-1/PD-L1) immune checkpoints have improved the treatments of cancers. However, not …

There are health benefits from consuming cruciferous vegetables that release indole-3-
carbinol (I3C), but the in vivo transformation of I3C-related indoles remains …

Folate metabolism is a target for various chemotherapeutic drugs. Folate and its synthetic
variant folic acid are B-vitamins. To what extent these vitamins impact treatment tolerance in …

Background Oncogenic transformation alters intracellular metabolism and contributes to the
growth of malignant cells. Metabolomics, or the study of small molecules, can reveal insight …

Autoimmune hepatitis (AIH), characterized by immune-driven liver destruction and cytokine
production, is a progressive inflammatory liver condition that may progress to hepatic …

Several chemotherapeutic agents are known to induce lacrimal drainage stenosis and
obstruction, resulting in epiphora. Pemetrexed is one such drug and is used in the …

Pemetrexed disodium (PMX) stands out in the treatment of non-small cell lung cancer
(NSCLC), but with short half-life and toxic side effects. This study was to design cationic …

Abstract Pemetrexed (PEM), a multi-target folate antagonist, has been extensively used for
the treatment of non-small cell lung cancer (NSCLC). However, the therapeutic efficacy of …

Methotrexate (MTX) is an antifolate drug used as a chemotherapeutic agent for acute
lymphoblastic leukemia, where MTX improves patients' prognosis. Macrophage …