Recent advances in monoclonal antibody-based approaches in the management of bacterial sepsis

K Kharga, L Kumar, SKS Patel - Biomedicines, 2023 - mdpi.com
Sepsis is a life-threatening condition characterized by an uncontrolled inflammatory
response to an infectious agent and its antigens. Immune cell activation against the antigens …

Production of monoclonal antibodies for therapeutic purposes: A review

WP Alejandra, JPM Irene, GSF Antonio… - International …, 2023 - Elsevier
Monoclonal antibodies (mAbs) have been used in the development of immunotherapies that
target a variety of diseases, such as cancer, autoimmune diseases, and even viral infections; …

Waning immunity and IgG4 responses following bivalent mRNA boosting

N Lasrado, AY Collier, J Miller, NP Hachmann, J Liu… - Science …, 2024 - science.org
Messenger RNA (mRNA) vaccines were highly effective against the ancestral SARS-CoV-2
strain, but the efficacy of bivalent mRNA boosters against XBB variants was substantially …

[HTML][HTML] Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections

KJ Selva, P Ramanathan, ER Haycroft, A Reynaldi… - JCI insight, 2023 - ncbi.nlm.nih.gov
Understanding mucosal antibody responses from SARS-CoV-2 infection and/or vaccination
is crucial to develop strategies for longer term immunity, especially against emerging viral …

[PDF][PDF] Systemic vasculitis: one year in review 2022

G La Rocca, G Del Frate, P Delvino… - Clin Exp …, 2022 - clinexprheumatol.org
Systemic vasculitis are rare heterogeneous disorders potentially involving any organ and
system with a relevant burden of mortality and comorbidity. As in the previous annual …

Pathophysiological effects of autoantibodies in autoimmune encephalitides

M Ryding, AW Mikkelsen, MS Nissen, AC Nilsson… - Cells, 2023 - mdpi.com
The heterogeneity of autoantibody targets in autoimmune encephalitides presents a
challenge for understanding cellular and humoral pathophysiology, and the development of …

Serological and molecular characterization of hepatitis C virus-related cryoglobulinemic vasculitis in patients without cryoprecipitate

C Napodano, G Ciasca, P Chiusolo, K Pocino… - International Journal of …, 2023 - mdpi.com
Prolonged B cells stimulation due to the Hepatitis C virus (HCV) can result in autoimmunity,
stigmatized by rising levels of cryoglobulins (CGs), the rheumatoid factor (RF), and free light …

Collision induced unfolding enables the quantitation of Isomass biotherapeutics in complex biological matrices

BR Juliano, BT Ruotolo - Journal of the American Society for …, 2023 - ACS Publications
Quantitative mass spectrometry has been widely used to evaluate the concentrations of
molecules within a variety of biological matrices. Typically, such quantitative mass …

Emerging Methods in Biosensing of Immunoglobin G—A Review

T Azam, SH Bukhari, U Liaqat, W Miran - Sensors, 2023 - mdpi.com
Human antibodies are produced due to the activation of immune system components upon
exposure to an external agent or antigen. Human antibody G, or immunoglobin G (IgG) …

[HTML][HTML] Therapeutic plasma exchange versus FcRn inhibition in autoimmune disease

P Mina-Osorio, MH Tran, AA Habib - Transfusion Medicine Reviews, 2023 - Elsevier
Therapeutic plasma exchange (TPE or PLEX) is used in a broad range of autoimmune
diseases, with the goal of removing autoantibodies from the circulation. A newer approach …