Cryptococcus neoformans is a major cause of fungal meningoencephalitis in
immunocompromised patients. Despite recent advances in the genetics and molecular …

The ability to thrive at 37° C is characteristic of all human pathogens and has long been
suspected to play a role in the pathogenesis of aspergillosis. As a thermotolerant fungus …

In 1999, the population of Vancouver Island, Canada, began to experience an outbreak of a
fatal fungal disease caused by a highly virulent lineage of Cryptococcus gattii. This organism …

The ability of fungi to grow well at mammalian body temperatures is a fundamental
characteristic of invasive human fungal pathogens. Cryptococcus neoformans, with its …

Cryptococcosis is an opportunistic infection due to the ubiquitous yeast Cryptococcus
neoformans. This yeast interacts closely with innate immune cells, leading to various fates …

The study of regulatory networks in human pathogens such as Cryptococcus neoformans
provides insights into host-pathogen interactions that may allow for correlation of gene …

Cryptococcosis is a multifaceted fungal infection with variable clinical presentation and
outcome. As in many infectious diseases, this variability is commonly assigned to host …

The ability to survive and proliferate at 37° C is an essential virulence attribute of pathogenic
microorganisms. A partial-genome microarray was used to profile gene expression in the …

The ubiquitous environmental human pathogen Cryptococcus neoformans is traditionally
considered a haploid fungus with a bipolar mating system. In nature, the α mating type is …

Virulence of Cryptococcus neoformans for mammals, and in particular its intracellular style,
was proposed to emerge from evolutionary pressures on its natural environment by …