Therapeutic application of natural products: NAD+ metabolism as potential target

C Guo, Q Huang, Y Wang, Y Yao, J Li, J Chen, M Wu… - Phytomedicine, 2023 - Elsevier
Background: Nicotinamide adenine dinucleotide (NAD+) metabolism is involved in the entire
physiopathological process and is critical to human health. Long-term imbalance in NAD+ …

[HTML][HTML] Targeting NAD metabolism for the therapy of age-related neurodegenerative diseases

F Li, C Wu, G Wang - Neuroscience Bulletin, 2024 - Springer
As the aging population continues to grow rapidly, age-related diseases are becoming an
increasing burden on the healthcare system and a major concern for the well-being of …

[HTML][HTML] Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model

W Zhao, C Ji, J Zheng, S Zhou, J Tian, Y Han… - Chinese Herbal …, 2024 - Elsevier
Objective This study aimed to investigate the therapeutic effects of Xiaoyao San (XYS), a
herbal medicine formula, on exercise capacity and liver mitochondrial metabolomics in a rat …

Exploring the adverse effects of 1, 3, 6, 8-tetrabromo-9H-carbazole in atherosclerotic model mice by metabolomic profiling integrated with mechanism studies in vitro

T Xu, Y Jiang, H Fu, G Yang, X Hu, Y Chen, Q Zhang… - Chemosphere, 2024 - Elsevier
Given its wide distribution in the environment and latent toxic effects, 1, 3, 6, 8-tetrabromo-
9H-carbazole (1368-BCZ) is an emerging concern that has gained increasing attention …

Study on the underlying mechanism of Poria in intervention of arrhythmia zebrafish by integrating metabolomics and network pharmacology

H Yang, YR Liu, ZX Song, ZS Tang, AL Jia, MG Wang… - Phytomedicine, 2024 - Elsevier
Background Poria is an herb with both medicinal and dietary application. It has been used in
various traditional Chinese patent medicines and medicinal decoctions for the treatment of …

[PDF][PDF] Integrated network pharmacology and brain metabolomics to analyze the mechanism of Dihuang Yinzi intervention in Alzheimer's disease

J Zhang, Q Li, B Yan, Q Wang, Y Zhou - Heliyon, 2024 - cell.com
Ethnopharmacological relevance Alzheimer's disease (AD) is an incurable
neurodegenerative disease that has become one of the most important diseases threatening …

[HTML][HTML] Advances in the study of the role of chemokines in drug addiction and the potential effects of traditional Chinese medicines

ZX Liu, XQ Wang, A Haghparast, WB He… - Brain Behavior and …, 2023 - Elsevier
Drug abuse significantly affects the neuroimmune system, which in turn contributes to the
development of addiction. Chemokines, the critical components of neuroimmune factors …

基于miRNA 机制研究中药抗阿尔茨海默病作用机制的研究进展.

张彩霞, 刘然, 陈洁 - Journal of Modern Medicine & …, 2023 - search.ebscohost.com
阿尔茨海默病(alzheimer'sdisease, AD) 好发于65 岁以上老年人, 目前尚无有效的治疗方法.
我国约有700 万AD 患者, 并且呈逐年上升的趋势, 预计2040 年我国将成为世界上AD …

Neuroprotective Mechanisms and Metabolomics Analysis of Jiedu Yizhi Formula in Alzheimer's Disease

Y Li, J Yan, T Cui, D Chen, X Zhu, J Wang, X Zhang… - 2024 - researchsquare.com
Aim of the study: We studied the metabolites in the brain tissue of Alzheimer's Disease (AD)
transgenic mice to investigate how Jiedu Yizhi Formula (JDYZF) protects against AD and to …