The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

Background The complement system is an essential component of our innate defense and
plays a vital role in the pathogenesis of many diseases. Assessment of complement …

Objectives Uncontrolled thromboinflammation plays an important role in the pathogenesis of
coronavirus disease (COVID-19) caused by SARS-CoV-2 virus. Complement was implicated …

Complement defects are associated with an enhanced risk of a broad spectrum of infectious
as well as systemic or local inflammatory and thrombotic disorders. Inherited complement …

In the past 20 years, we have witnessed tremendous advances in our ability to diagnose and
treat genetic diseases of the kidney caused by complement dysregulation. Staggering …

The soluble membrane attack complex (sMAC, aka, sC5b-9 or TCC) is generated on
activation of complement and contains the complement proteins C5b, C6, C7, C8, C9 …

Inflammation is a common denominator of diseases. The complement system, an intrinsic
part of the innate immune system, is a key driver of inflammation in numerous disorders …

Complement not only plays a key role in host microbial defense but also modulates the
adaptive immune response through modification of T-and B-cell reactivity. Moreover, a …

Introduction Overactivation of the lectin pathway of complement plays a pathogenic role in a
broad range of immune-mediated and inflammatory disorders; mannan-binding lectin …

After years of disappointing clinical results, the tide has finally changed and complement
targeted-therapies have become a validated and accepted treatment option for several …