Background Activation of the PI3K/AKT/mTOR pathway through loss of phosphatase and
tensin homolog (PTEN) occurs in approximately 50% of patients with metastatic castration …

BACKGROUND New therapies are required for castrate‐resistant prostate cancer (CRPC),
and growth‐arrest specific 5 (GAS5) lncRNA, which riborepresses androgen receptor action …

The largest US cancer health disparity exists in prostate cancer, with Black men having more
than a two-fold increased risk of dying from prostate cancer compared to all other races. This …

Prostate cancer (PCa) is the second leading cause of cancer death in American men.
Androgen receptor (AR) signaling is essential for PCa cell growth/survival and remains a …

Abstract Background The phosphatidylinositol-4, 5-bisphosphate 3-kinase (PI3K)/AKT
pathway is frequently activated during prostate cancer (PCa) progression through loss or …

Abstract The phosphatidylinositol-4, 5-bisphosphate 3-kinase/Akt (PI3K/Akt) pathway is a
key pathway activated in castrate-resistant prostate cancer (CRPC). This preclinical study …

Activation of Hedgehog (Hh) signaling is implicated in the development and progression of
several tumor types, including prostate cancer, which is still the most common non-skin …

Background Prostate cancer is one of leading causes of cancer death among men
worldwide. Androgen deprivation therapy is a central part of the prostate cancer treatment …

Context Genomic testing is becoming increasingly important in patients with advanced
prostate cancer (PC) and is being incorporated in clinical practice to guide treatment …

Altered glutamine metabolism is a hallmark of cancer growth, forming the theoretical basis
for development of metabolic therapies as cancer treatments. Glutaminase (GLS), a crucial …