Urothelial carcinoma of the bladder is the most frequent tumor of the urinary tract and
represents the fifth cause of death by cancer worldwide. The current first line chemotherapy …

It is now understood that persistent activation of the androgen receptor (AR) signaling
pathway often underlies the development of castration-resistant prostate cancer (CRPC) …

The endoplasmic reticulum (ER) is an essential organelle that contributes to several key
cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle …

Abstract Purpose: The PI3K/Akt/mTOR pathway is activated in most castration-resistant
prostate cancers (CRPC). Transcriptionally active androgen receptor (AR) plays a role in the …

New Findings What is the central question of this study? What is the role of lncRNA PRRT3‐
AS1 in the regulation of peroxisome proliferator‐activated receptor γ (PPARγ) gene …

Background Human prostate cancer represents one of the most frequently diagnosed
cancers in men worldwide. Currently, diagnostic methods are insufficient to identify patients …

Targeting the androgen receptor (AR) signalling pathway remains the main therapeutic
option for advanced prostate cancer. However, resistance to AR‐targeting inhibitors …

Castration-resistant prostate cancer (CRPC) is a lethal disease, and improvement with
androgen-deprivation therapy has plateaued. Next-generation sequencing studies have led …

Upregulation of MYC and miRNAs deregulation are common in prostate cancer (PCa).
Overactive MYC may cause miRNAs' expression deregulation through transcriptional and …

Abstract Prostate Cancer (PCa) is an important age-related disease being the most common
cancer malignancy and the second leading cause of cancer mortality in men in Western …