MLL-rearranged leukemias—an update on science and clinical approaches
AC Winters, KM Bernt - Frontiers in pediatrics, 2017 - frontiersin.org
The mixed-lineage leukemia 1 (MLL1) gene (now renamed Lysine [K]-specific
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
MethylTransferase 2A or KMT2A) on chromosome 11q23 is disrupted in a unique group of …
Cytogenetics of pediatric acute myeloid leukemia: a review of the current knowledge
J Quessada, W Cuccuini, P Saultier, M Loosveld… - Genes, 2021 - mdpi.com
Pediatric acute myeloid leukemia is a rare and heterogeneous disease in relation to
morphology, immunophenotyping, germline and somatic cytogenetic and genetic …
morphology, immunophenotyping, germline and somatic cytogenetic and genetic …
A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia
Chromosomal rearrangements without gene fusions have been implicated in
leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic …
leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic …
MLL-AF9 expression in hematopoietic stem cells drives a highly invasive AML expressing EMT-related genes linked to poor outcome
V Stavropoulou, S Kaspar, L Brault, MA Sanders… - Cancer cell, 2016 - cell.com
To address the impact of cellular origin on acute myeloid leukemia (AML), we generated an
inducible transgenic mouse model for MLL-AF9-driven leukemia. MLL-AF9 expression in …
inducible transgenic mouse model for MLL-AF9-driven leukemia. MLL-AF9 expression in …
Cell of origin determines clinically relevant subtypes of MLL-rearranged AML
Mixed lineage leukemia (MLL)-fusion proteins can induce acute myeloid leukemias (AMLs)
from either hematopoietic stem cells (HSCs) or granulocyte–macrophage progenitors …
from either hematopoietic stem cells (HSCs) or granulocyte–macrophage progenitors …
Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing
W Arindrarto, DM Borràs, RAL de Groen… - Leukemia, 2021 - nature.com
Acute myeloid leukemia (AML) is caused by genetic aberrations that also govern the
prognosis of patients and guide risk-adapted and targeted therapy. Genetic aberrations in …
prognosis of patients and guide risk-adapted and targeted therapy. Genetic aberrations in …
A genetic disorder reveals a hematopoietic stem cell regulatory network co-opted in leukemia
The molecular regulation of human hematopoietic stem cell (HSC) maintenance is
therapeutically important, but limitations in experimental systems and interspecies variation …
therapeutically important, but limitations in experimental systems and interspecies variation …
Murine models of acute myeloid leukaemia
M Almosailleakh, J Schwaller - International journal of molecular sciences, 2019 - mdpi.com
Acute myeloid leukaemia (AML) is a rare but severe form of human cancer that results from a
limited number of functionally cooperating genetic abnormalities leading to uncontrolled …
limited number of functionally cooperating genetic abnormalities leading to uncontrolled …
Deregulated Expression of EVI1 Defines a Poor Prognostic Subset of MLL-Rearranged Acute Myeloid Leukemias: A Study of the German-Austrian Acute Myeloid …
S Groeschel, RF Schlenk, J Engelmann… - Journal of clinical …, 2013 - ascopubs.org
Purpose To evaluate the prognostic value of ecotropic viral integration 1 gene (EVI1)
overexpression in acute myeloid leukemia (AML) with MLL gene rearrangements. Patients …
overexpression in acute myeloid leukemia (AML) with MLL gene rearrangements. Patients …
EVI1 dysregulation: impact on biology and therapy of myeloid malignancies
C Birdwell, W Fiskus, TM Kadia, CD DiNardo… - Blood cancer …, 2021 - nature.com
Ecotropic viral integration site 1 (Evi1) was discovered in 1988 as a common site of
ecotropic viral integration resulting in myeloid malignancies in mice. EVI1 is an oncogenic …
ecotropic viral integration resulting in myeloid malignancies in mice. EVI1 is an oncogenic …