There are a variety of medical conditions associated with chronic sinonasal inflammation,
including chronic rhinosinusitis (CRS) and cystic fibrosis. In particular, CRS can be divided …

Taste receptors were first identified on the tongue, where they initiate a signaling pathway
that communicates information to the brain about the nutrient content or potential toxicity of …

Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many
tissues outside the tongue, have recently become potential therapeutic targets. We have …

In the upper respiratory epithelium, bitter and sweet taste receptors present in solitary
chemosensory cells influence antimicrobial innate immune defense responses. Whereas …

Chronic rhinosinusitis has a significant impact on patient quality of life, creates billions of
dollars of annual healthcare costs, and accounts for∼ 20% of adult antibiotic prescriptions in …

Introduction Bitter taste receptors (T2Rs) are G protein-coupled receptors identified on the
tongue but expressed all over the body, including in airway cilia and macrophages, where …

We previously observed that the human bitter taste receptor T2R38 is an important
component of upper respiratory innate defense because it detects acyl homoserine lactone …

Background Protecting the upper airway from microbial infection is an important function of
the immune system. Proper detection of these pathogens is paramount for sinonasal …

Aflatoxins are mycotoxins secreted by Aspergillus flavus, which can colonize the respiratory
tract and cause fungal rhinosinusitis or bronchopulmonary aspergillosis. A. flavus is the …

Background In the past, the airway epithelium was thought to be primarily an inert physical
barrier. We now know that the upper airway epithelium plays a critical role in both innate and …