Molecular Testing for Diagnostics, Prognostication, and Treatment Stratification in Cancers
S Heneidi, JA Golden, E Vail - The Cancer Journal, 2023 - journals.lww.com
Precision cancer care, for essentially all cancer types, now requires molecular diagnostics to
assess mutations, chromosomal alterations, and gene expression to personalize treatments …
assess mutations, chromosomal alterations, and gene expression to personalize treatments …
Plasma versus tissue tumor mutational burden as biomarkers of durvalumab plus tremelimumab response in patients with metastatic colorectal cancer in the CO. 26 …
Purpose: Tissue derived tumor mutation burden (TMB) of≥ 10 mutations/Mb is a histology
agnostic biomarker for the immune checkpoint inhibitor (ICI) pembrolizumab. However, the …
agnostic biomarker for the immune checkpoint inhibitor (ICI) pembrolizumab. However, the …
[HTML][HTML] Immune activation following Irbesartan treatment in a colorectal cancer patient: a case study
E Titmuss, K Milne, MR Jones, T Ng… - International Journal of …, 2023 - mdpi.com
Colorectal cancers are one of the most prevalent tumour types worldwide and, despite the
emergence of targeted and biologic therapies, have among the highest mortality rates. The …
emergence of targeted and biologic therapies, have among the highest mortality rates. The …
[HTML][HTML] Detecting Somatic Mutations Without Matched Normal Samples Using Long Reads
JT Simpson - bioRxiv, 2024 - ncbi.nlm.nih.gov
DNA sequencing of tumours to identify somatic mutations has become a critical tool to guide
the type of treatment given to cancer patients. The gold standard for mutation calling is …
the type of treatment given to cancer patients. The gold standard for mutation calling is …
Mapping in silico genetic networks of the KMT2D tumour suppressor gene to uncover novel functional associations and cancer cell vulnerabilities
Loss-of-function (LOF) alterations in tumour suppressor genes cannot be directly targeted.
Approaches characterising gene function and vulnerabilities conferred by such mutations …
Approaches characterising gene function and vulnerabilities conferred by such mutations …
Mapping in silico genetic networks of tumour suppressor genes to uncover novel gene functions and predict cancer cell vulnerabilities
Y Takemon - 2024 - open.library.ubc.ca
Sequencing technologies have advanced the discovery of cancer-related genes. However,
the functional impact of mutations in these genes and the effect of their mutated forms on a …
the functional impact of mutations in these genes and the effect of their mutated forms on a …