Breast cancer, as one of the most common invasive malignancies and the leading cause of
cancer‐related deaths in women globally, poses a significant challenge in the world health …

Synthetic chemists have organized easy and effective ways for perfect synthesis in response
to the requirement for scaffolds that are crucial for medical applications. A general strategy …

A series of 20 novel gefitinib derivatives incorporating the 1, 2, 3-triazole moiety were
designed and synthesized. The synthesized compounds were evaluated for their potential …

Abstract The reaction of 4‐(chloroacetamido) pyrimidine (1) with ammonium thiocyanate
gave 2‐(pyrimidin‐4‐ylimino) thiazolidin‐4‐one (2), which, when condensed with four …

Amino-1, 3-dimethyluracil (1) has two electron donating centres (NH 2 and C-5) and its
chemical reactivity was investigated towards a variety of electrophilic reagents hoping to …

In this study, we designed and synthesized several novel fused [1, 2, 3] triazolo [4′, 5′: 3,
4] pyrrolo [2, 1-b] quinazolinone derivatives using a single [3+ 2] reaction cycloaddition …

The thiazole ring closure of thiosemicarbazones with α-bromo-4-substituted acetophenones
was carried out to generate aminothiazole analogues (A1–A16). Experimental methods …

In this study, we designed and synthesized several novel fused [1, 2, 3] triazolo [4′, 5′: 3,
4] pyrrolo [1, 2‐a] thieno [2, 3‐d] pyrimidine derivatives using in a single [3+ 2] reaction …

In this study, we designed and synthesized a number of novel pyrido [3, 4‐d] pyrimidine‐
thiazolidine‐1, 2, 4‐oxadiazole derivatives and investigated them in vitro for their inhibitory …

A variety of new pyrido [2, 3-d] pyrimidine-piperazine-1, 2, 4-oxadiazoles was synthesized
and tested in vitro for their ability to inhibit EGFR kinases and their anti-cancer activity …