The anti‐breast cancer therapeutic potential of 1, 2, 3‐triazole‐containing hybrids
J Song, S Zhang, B Zhang, J Ma - Archiv der Pharmazie, 2024 - Wiley Online Library
Breast cancer, as one of the most common invasive malignancies and the leading cause of
cancer‐related deaths in women globally, poses a significant challenge in the world health …
cancer‐related deaths in women globally, poses a significant challenge in the world health …
Synthesis of [1, 2, 4] triazolo [3, 4-b][1, 3, 4] thiadiazine-1, 2, 3-triazoles as potent EGFR targeting anti-breast cancer agents
Synthetic chemists have organized easy and effective ways for perfect synthesis in response
to the requirement for scaffolds that are crucial for medical applications. A general strategy …
to the requirement for scaffolds that are crucial for medical applications. A general strategy …
[HTML][HTML] Discovery of gefitinib-1, 2, 3-triazole derivatives against lung cancer via inducing apoptosis and inhibiting the colony formation
E Gao, Y Wang, G Fan, G Xu, ZY Wu, ZJ Liu, JC Liu… - Scientific Reports, 2024 - nature.com
A series of 20 novel gefitinib derivatives incorporating the 1, 2, 3-triazole moiety were
designed and synthesized. The synthesized compounds were evaluated for their potential …
designed and synthesized. The synthesized compounds were evaluated for their potential …
Synthesis, photophysical properties, anticancer evaluation, and molecular docking studies of new pyrimidine linked 4‐arylidene‐thiazolidin‐4‐ones as potent …
R Jame - Luminescence, 2024 - Wiley Online Library
Abstract The reaction of 4‐(chloroacetamido) pyrimidine (1) with ammonium thiocyanate
gave 2‐(pyrimidin‐4‐ylimino) thiazolidin‐4‐one (2), which, when condensed with four …
gave 2‐(pyrimidin‐4‐ylimino) thiazolidin‐4‐one (2), which, when condensed with four …
Synthetic approaches for novel annulated pyrido [2, 3-d] pyrimidines: Design, Structural Characterization, Fukui functions, DFT Calculations, Molecular docking and …
Z Hussain, MA Ibrahim, NM Hassanin… - Journal of Molecular …, 2024 - Elsevier
Amino-1, 3-dimethyluracil (1) has two electron donating centres (NH 2 and C-5) and its
chemical reactivity was investigated towards a variety of electrophilic reagents hoping to …
chemical reactivity was investigated towards a variety of electrophilic reagents hoping to …
One-pot synthesis, anticancer, EGFR and caspases assays of novel fused [1, 2, 3] triazolo-pyrrolo [2, 1-b] quinazolinones
N Udayasree, RB Haridasyam, R Palabindela… - Journal of Molecular …, 2024 - Elsevier
In this study, we designed and synthesized several novel fused [1, 2, 3] triazolo [4′, 5′: 3,
4] pyrrolo [2, 1-b] quinazolinone derivatives using a single [3+ 2] reaction cycloaddition …
4] pyrrolo [2, 1-b] quinazolinone derivatives using a single [3+ 2] reaction cycloaddition …
Synthesis, docking studies, in silico ADMET predictions, DFT calculations, and photophysical properties of thiazole-anthracene hybrids as potent EGFR inhibitors
R Palabindela, R Bodapati, P Myadaraveni… - Journal of Molecular …, 2024 - Elsevier
The thiazole ring closure of thiosemicarbazones with α-bromo-4-substituted acetophenones
was carried out to generate aminothiazole analogues (A1–A16). Experimental methods …
was carried out to generate aminothiazole analogues (A1–A16). Experimental methods …
Synthesis of novel [1,2,3]triazolo[4′,5′:3,4]pyrrolo[1,2‐a]thieno[2,3‐d] pyrimidines: Potent EGFR targeting anti‐breast cancer agents
R Samala, AK Bapuram, V Nasipireddy… - Journal of …, 2024 - Wiley Online Library
In this study, we designed and synthesized several novel fused [1, 2, 3] triazolo [4′, 5′: 3,
4] pyrrolo [1, 2‐a] thieno [2, 3‐d] pyrimidine derivatives using in a single [3+ 2] reaction …
4] pyrrolo [1, 2‐a] thieno [2, 3‐d] pyrimidine derivatives using in a single [3+ 2] reaction …
Synthesis of novel pyrido[3,4‐d]pyrimidine‐thiazolidione‐1,2,4‐oxadiazoles as potent EGFR targeting anticancer agents
BD Varaprasadu, SB Haridasyam… - Journal of Heterocyclic …, 2024 - Wiley Online Library
In this study, we designed and synthesized a number of novel pyrido [3, 4‐d] pyrimidine‐
thiazolidine‐1, 2, 4‐oxadiazole derivatives and investigated them in vitro for their inhibitory …
thiazolidine‐1, 2, 4‐oxadiazole derivatives and investigated them in vitro for their inhibitory …
Synthesis, Anti-Breast Cancer, and EGFR Activity of Novel Pyrido[2,3-d]pyrimidine-piperazine-1,2,4-oxadiazoles
G Jyothi, R Palabindela, S Narsimha - Russian Journal of General …, 2024 - Springer
A variety of new pyrido [2, 3-d] pyrimidine-piperazine-1, 2, 4-oxadiazoles was synthesized
and tested in vitro for their ability to inhibit EGFR kinases and their anti-cancer activity …
and tested in vitro for their ability to inhibit EGFR kinases and their anti-cancer activity …