Oxidative stress and neuroinflammation potentiate each other to promote progression of dopamine neurodegeneration
J He, G Zhu, G Wang, F Zhang - Oxidative medicine and …, 2020 - Wiley Online Library
Parkinson's disease (PD) is a chronic and complex disease of the central nervous system
(CNS). Progressive loss of dopamine (DA) neurons in midbrain substantia nigra is …
(CNS). Progressive loss of dopamine (DA) neurons in midbrain substantia nigra is …
Roles of clock genes in the pathogenesis of Parkinson's disease
AD Shkodina, SC Tan, MM Hasan… - Ageing Research …, 2022 - Elsevier
Parkinson's disease (PD) is a common motor disorder that has become increasingly
prevalent in the ageing population. Recent works have suggested that circadian rhythms …
prevalent in the ageing population. Recent works have suggested that circadian rhythms …
[HTML][HTML] Roles of α‑synuclein in gastrointestinal microbiome dysbiosis‑related Parkinson's disease progression
Q Lei, T Wu, J Wu, X Hu, Y Guan… - Molecular …, 2021 - spandidos-publications.com
Parkinson's disease (PD) is the second most common neurodegenerative disease amongst
the middle‑aged and elderly populations. Several studies have confirmed that the microbiota …
the middle‑aged and elderly populations. Several studies have confirmed that the microbiota …
Resveratrol delays 6-hydroxydopamine-induced apoptosis by activating the PI3K/Akt signaling pathway
N Huang, Y Zhang, M Chen, H Jin, J Nie, Y Luo… - Experimental …, 2019 - Elsevier
This study aimed to determine whether resveratrol (Res) delays the progression of 6-
hydroxydopamine (6-OHDA)-induced apoptosis via activating the phosphoinositide 3-kinase …
hydroxydopamine (6-OHDA)-induced apoptosis via activating the phosphoinositide 3-kinase …
[HTML][HTML] Menaquinone-4 suppresses lipopolysaccharide-induced inflammation in MG6 mouse microglia-derived cells by inhibiting the NF-κB signaling pathway
WD Saputra, N Aoyama, M Komai… - International journal of …, 2019 - mdpi.com
The overactivation of microglia is known to trigger inflammatory reactions in the central
nervous system, which ultimately induce neuroinflammatory disorders including Alzheimer's …
nervous system, which ultimately induce neuroinflammatory disorders including Alzheimer's …
[HTML][HTML] Phenothiazine normalizes the NADH/NAD+ ratio, maintains mitochondrial integrity and protects the nigrostriatal dopamine system in a chronic rotenone …
Impaired mitochondrial function has been associated with the etiopathogenesis of
Parkinson's disease (PD). Sustained inhibition of complex I produces mitochondrial …
Parkinson's disease (PD). Sustained inhibition of complex I produces mitochondrial …
Protective role of cinnabar and realgar in Hua-Feng-Dan against LPS plus rotenone-induced neurotoxicity and disturbance of gut microbiota in rats
C Chen, BB Zhang, AL Hu, H Li, J Liu… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Hua-Feng-Dan (HFD) is a traditional Chinese
medicine used for neurological disorders. HFD contains cinnabar (HgS) and realgar (As 4 S …
medicine used for neurological disorders. HFD contains cinnabar (HgS) and realgar (As 4 S …
Mercury sulfide-containing Hua-Feng-Dan and 70W (Rannasangpei) protect against LPS plus MPTP-induced neurotoxicity and disturbance of gut microbiota in mice
Abstract Ethnopharmacological relevance Mercury sulfides (HgS) are frequently included in
Ayurveda, Tibetan and Chinese medicines to assist the presumed therapeutic effects, but …
Ayurveda, Tibetan and Chinese medicines to assist the presumed therapeutic effects, but …
Low-grade inflammation aggravates rotenone neurotoxicity and disrupts circadian clock gene expression in rats
H Li, S Song, Y Wang, C Huang, F Zhang, J Liu… - Neurotoxicity …, 2019 - Springer
A single injection of LPS produced low-grade neuroinflammation leading to Parkinson's
disease (PD) in mice several months later. Whether such a phenomenon occurs in rats and …
disease (PD) in mice several months later. Whether such a phenomenon occurs in rats and …
Synergistic effects of lipopolysaccharide and rotenone on dopamine neuronal damage in rats
JY He, DD Li, Q Wen, TY Qin, H Long… - CNS Neuroscience …, 2023 - Wiley Online Library
Abstract Introduction The etiology of Parkinson's disease (PD) is still unknown. Until now,
oxidative stress and neuroinflammation play a crucial role in the pathogenesis of PD …
oxidative stress and neuroinflammation play a crucial role in the pathogenesis of PD …