Oxidative stress and neuroinflammation potentiate each other to promote progression of dopamine neurodegeneration

J He, G Zhu, G Wang, F Zhang - Oxidative medicine and …, 2020 - Wiley Online Library
Parkinson's disease (PD) is a chronic and complex disease of the central nervous system
(CNS). Progressive loss of dopamine (DA) neurons in midbrain substantia nigra is …

Roles of clock genes in the pathogenesis of Parkinson's disease

AD Shkodina, SC Tan, MM Hasan… - Ageing Research …, 2022 - Elsevier
Parkinson's disease (PD) is a common motor disorder that has become increasingly
prevalent in the ageing population. Recent works have suggested that circadian rhythms …

[HTML][HTML] Roles of α‑synuclein in gastrointestinal microbiome dysbiosis‑related Parkinson's disease progression

Q Lei, T Wu, J Wu, X Hu, Y Guan… - Molecular …, 2021 - spandidos-publications.com
Parkinson's disease (PD) is the second most common neurodegenerative disease amongst
the middle‑aged and elderly populations. Several studies have confirmed that the microbiota …

Resveratrol delays 6-hydroxydopamine-induced apoptosis by activating the PI3K/Akt signaling pathway

N Huang, Y Zhang, M Chen, H Jin, J Nie, Y Luo… - Experimental …, 2019 - Elsevier
This study aimed to determine whether resveratrol (Res) delays the progression of 6-
hydroxydopamine (6-OHDA)-induced apoptosis via activating the phosphoinositide 3-kinase …

[HTML][HTML] Menaquinone-4 suppresses lipopolysaccharide-induced inflammation in MG6 mouse microglia-derived cells by inhibiting the NF-κB signaling pathway

WD Saputra, N Aoyama, M Komai… - International journal of …, 2019 - mdpi.com
The overactivation of microglia is known to trigger inflammatory reactions in the central
nervous system, which ultimately induce neuroinflammatory disorders including Alzheimer's …

[HTML][HTML] Phenothiazine normalizes the NADH/NAD+ ratio, maintains mitochondrial integrity and protects the nigrostriatal dopamine system in a chronic rotenone …

V Tapias, JL McCoy, JT Greenamyre - Redox Biology, 2019 - Elsevier
Impaired mitochondrial function has been associated with the etiopathogenesis of
Parkinson's disease (PD). Sustained inhibition of complex I produces mitochondrial …

Protective role of cinnabar and realgar in Hua-Feng-Dan against LPS plus rotenone-induced neurotoxicity and disturbance of gut microbiota in rats

C Chen, BB Zhang, AL Hu, H Li, J Liu… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Hua-Feng-Dan (HFD) is a traditional Chinese
medicine used for neurological disorders. HFD contains cinnabar (HgS) and realgar (As 4 S …

Mercury sulfide-containing Hua-Feng-Dan and 70W (Rannasangpei) protect against LPS plus MPTP-induced neurotoxicity and disturbance of gut microbiota in mice

AL Hu, S Song, Y Li, SF Xu, F Zhang, C Li… - Journal of …, 2020 - Elsevier
Abstract Ethnopharmacological relevance Mercury sulfides (HgS) are frequently included in
Ayurveda, Tibetan and Chinese medicines to assist the presumed therapeutic effects, but …

Low-grade inflammation aggravates rotenone neurotoxicity and disrupts circadian clock gene expression in rats

H Li, S Song, Y Wang, C Huang, F Zhang, J Liu… - Neurotoxicity …, 2019 - Springer
A single injection of LPS produced low-grade neuroinflammation leading to Parkinson's
disease (PD) in mice several months later. Whether such a phenomenon occurs in rats and …

Synergistic effects of lipopolysaccharide and rotenone on dopamine neuronal damage in rats

JY He, DD Li, Q Wen, TY Qin, H Long… - CNS Neuroscience …, 2023 - Wiley Online Library
Abstract Introduction The etiology of Parkinson's disease (PD) is still unknown. Until now,
oxidative stress and neuroinflammation play a crucial role in the pathogenesis of PD …