Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent
kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as …

Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus
nidulans led to the discovery of never-in-mitosis A (NIMA), a serine/threonine kinase that is …

Posttranslational modification of cell-cycle regulators with ubiquitin chains is essential for
eukaryotic cell division. Such chains can be connected through seven lysine residues or the …

The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has
essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular …

The appropriate timing of events that lead to chromosome segregation during mitosis and
cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute …

One does not often look to analytic cubism for insights into the control of the cell cycle, but
Pablo Picasso beautifully encapsulated the fundamentals when he said that “every act of …

Two families of E3 ubiquitin ligases are prominent in cell cycle regulation and mediate the
timely and precise ubiquitin–proteasome-dependent degradation of key cell cycle proteins …

Abstract The Anaphase Promoting Complex (APC, also called APC/C) regulates cell cycle
progression by forming two closely related, but functionally distinct E3 ubiquitin ligase sub …

Protein kinases are pivotal regulators of cell signaling that modulate each other's functions
and activities through site-specific phosphorylation events. These key regulatory …

Protein machines are multi-subunit protein complexes that orchestrate highly regulated
biochemical tasks. An example is the anaphase-promoting complex/cyclosome (APC/C), a …