Rebalancing the addicted brain: oxytocin interference with the neural substrates of addiction

MT Bowen, ID Neumann - Trends in neurosciences, 2017 - cell.com
Drugs that act on the brain oxytocin (OXT) system may provide a much-needed treatment
breakthrough for substance-use disorders. Targeting the brain OXT system has the potential …

A systematic review and meta-analysis of 'Systems for Social Processes' in borderline personality and substance use disorders

L Hanegraaf, S van Baal, J Hohwy… - … & Biobehavioral Reviews, 2021 - Elsevier
Deficits in social processing (SP) have been proposed to underpin interpersonal dysfunction
in both Borderline Personality Disorder (BPD) and Substance Use Disorders (SUD). This …

Oxytocin reduces alcohol cue-reactivity in alcohol-dependent rats and humans

AC Hansson, A Koopmann, S Uhrig, S Bühler… - …, 2018 - nature.com
Approved pharmacological treatments for alcohol use disorder are limited in their
effectiveness, and new drugs that can easily be translated into the clinic are warranted. One …

What do you have in mind? Measures to assess mental state reasoning in neuropsychiatric populations

CM Eddy - Frontiers in psychiatry, 2019 - frontiersin.org
Social interaction is closely associated with both functional capacity and well-being.
Previous research has not only revealed evidence of social dysfunction in individuals with a …

Oxytocin enhances cognitive control of food craving in women

N Striepens, F Schröter, B Stoffel‐Wagner… - Human brain …, 2016 - Wiley Online Library
In developed countries, obesity has become an epidemic resulting in enormous health care
costs for society and serious medical complications for individuals. The homeostatic …

Craving and opioid use disorder: A scoping review

BA Kleykamp, M De Santis, RH Dworkin… - Drug and Alcohol …, 2019 - Elsevier
Introduction The subjective experience of drug craving is a prominent and common clinical
phenomenon for many individuals diagnosed with opioid use disorder (OUD), and could be …

The impact of early life stress on the central oxytocin system and susceptibility for drug addiction: Applicability of oxytocin as a pharmacotherapy

SJ Baracz, NA Everett, JL Cornish - Neuroscience & Biobehavioral …, 2020 - Elsevier
Early life trauma is strongly associated with an increased vulnerability to abuse illicit drugs
and the impairment of neural development. This includes alterations to the development of …

Oxytocin signaling in the treatment of drug addiction: Therapeutic opportunities and challenges

X Che, J Cai, Y Liu, T Xu, J Yang, C Wu - Pharmacology & therapeutics, 2021 - Elsevier
Drug addiction is one of the leading causes of mortality worldwide. Despite great advances
were achieved in understanding the neurobiology of drug addiction, the therapeutic options …

Oxytocin and opioid addiction revisited: old drug, new applications

P Zanos, P Georgiou, C Weber… - British journal of …, 2018 - Wiley Online Library
Opioid addiction has devastating health and socio‐economic consequences, and current
pharmacotherapy is limited and often accompanied by side effects, thus novel treatment is …

Can intranasal oxytocin reduce craving in automated addictive behaviours? A systematic review

B Houghton, C Kouimtsidis, T Duka… - British Journal of …, 2021 - Wiley Online Library
Existing pharmacotherapies for managing craving, a strong predictor of relapse to
automated addictive behaviours, are limited in efficacy and characterised by increased …