Abstract Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent
deacetylase, is a cellular regulator that has received extensive attention in recent years and …

Melatonin is synthesized in the pineal gland at night. Since melatonin is produced in the
mitochondria of all other cells in a non-circadian manner, the amount synthesized by the …

Oxidative stress is an important contributor to the development of osteoporosis. Melatonin,
an indoleamine secreted by the pineal gland, has antioxidant properties. This study aims to …

Studies suggested that psychosocial stress was associated with female fertility decline, but
the underlying mechanisms remained unclear. Granulosa cells (GCs) are important somatic …

Melatonin has not only to be seen as a regulator of circadian clocks. In addition to its
chronobiotic functions, it displays other actions, especially in cell protection. This includes …

Environmental challenges, specifically chronic stress, have long been associated with
neuropsychiatric disorders, including anxiety and depression. Sirtuin-1 (SIRT1) is a NAD+ …

Cyclophosphamide (CTX) is widely used in various cancer therapies and in
immunosuppression, and patients can still have babies after CTX chemotherapy. CTX …

Background Diminished ovarian reserve (DOR) significantly increases the risk of female
infertility and contributes to reproductive technology failure. Recently, the role of melatonin in …

Germ cell quality is a key prerequisite for successful fertilization and early embryo
development. The quality is determined by the fine regulation of transcriptomic and …

Premature ovarian insufficiency (POI), which is defined as loss of ovarian function that
occurs before the age of 40, causes menstrual disturbances, infertility, and diverse health …