The role of oxidative stress in physiopathology and pharmacological treatment with pro‐and antioxidant properties in chronic diseases

A García-Sánchez, AG Miranda-Díaz… - Oxidative Medicine …, 2020 - Wiley Online Library
Oxidative stress (OS) has the ability to damage different molecules and cellular structures,
altering the correct function of organs and systems. OS accumulates in the body by …

Pathophysiology of cardiovascular diseases: new insights into molecular mechanisms of atherosclerosis, arterial hypertension, and coronary artery disease

W Frąk, A Wojtasińska, W Lisińska, E Młynarska… - Biomedicines, 2022 - mdpi.com
Cardiovascular diseases (CVDs) are disorders associated with the heart and circulatory
system. Atherosclerosis is its major underlying cause. CVDs are chronic and can remain …

Endothelial dysfunction and hypertension

D Konukoglu, H Uzun - Hypertension: from basic research to clinical …, 2017 - Springer
In the past, endothelium was thought to be only a mechanical barrier. Today, endothelium is
known to be a tissue regulating vascular tone, cell growth and the interaction between the …

Hypertension and aging

TW Buford - Ageing research reviews, 2016 - Elsevier
Hypertension is a highly prevalent condition with numerous health risks, and the incidence
of hypertension is greatest among older adults. Traditional discussions of hypertension have …

Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension

QN Dinh, GR Drummond, CG Sobey… - BioMed research …, 2014 - Wiley Online Library
Hypertension is a complex condition and is the most common cardiovascular risk factor,
contributing to widespread morbidity and mortality. Approximately 90% of hypertension …

Gut microbiota promote angiotensin II–induced arterial hypertension and vascular dysfunction

SH Karbach, T Schönfelder, I Brandão… - Journal of the …, 2016 - Am Heart Assoc
Background The gut microbiome is essential for physiological host responses and
development of immune functions. The impact of gut microbiota on blood pressure and …

Hypertension in chronic kidney disease

SM Hamrahian, B Falkner - Hypertension: from basic research to clinical …, 2017 - Springer
Hypertension, a global public health problem, is currently the leading factor in the global
burden of disease. It is the major modifiable risk factor for heart disease, stroke and kidney …

OxInflammation: from subclinical condition to pathological biomarker

G Valacchi, F Virgili, C Cervellati, A Pecorelli - Frontiers in physiology, 2018 - frontiersin.org
Inflammation is a complex systemic response evolved to cope with cellular injury, either due
to infectious agents or, in general, with sporadic events challenging tissue integrity and …

Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?

SCS Brandao, JOX Ramos, LT Dompieri… - Cytokine & Growth …, 2021 - Elsevier
The severe form of COVID-19 is marked by an abnormal and exacerbated immunological
host response favoring to a poor outcome in a significant number of patients, especially …

Pharmacological and molecular insight on the cardioprotective role of apigenin

SD Thomas, NK Jha, SK Jha, B Sadek, S Ojha - Nutrients, 2023 - mdpi.com
Apigenin is a naturally occurring dietary flavonoid found abundantly in fruits and vegetables.
It possesses a wide range of biological properties that exert antioxidant, anti-inflammatory …