Understanding cachexia as a cancer metabolism syndrome
PE Porporato - Oncogenesis, 2016 - nature.com
Metabolic reprogramming occurs in tumors to foster cancer cell proliferation, survival and
metastasis, but as well at a systemic level affecting the whole organism, eventually leading …
metastasis, but as well at a systemic level affecting the whole organism, eventually leading …
HMGB1 in health and disease
R Kang, R Chen, Q Zhang, W Hou, S Wu, L Cao… - Molecular aspects of …, 2014 - Elsevier
Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …
emergence of chromosomal instability, development of unscheduled cell death, skewed …
Regulation of tumor progression by programmed necrosis
SY Lee, MK Ju, HM Jeon, EK Jeong… - Oxidative medicine …, 2018 - Wiley Online Library
Rapidly growing malignant tumors frequently encounter hypoxia and nutrient (eg, glucose)
deprivation, which occurs because of insufficient blood supply. This results in necrotic cell …
deprivation, which occurs because of insufficient blood supply. This results in necrotic cell …
Understanding the common mechanisms of heart and skeletal muscle wasting in cancer cachexia
V Rausch, V Sala, F Penna, PE Porporato, A Ghigo - Oncogenesis, 2021 - nature.com
Cachexia is a severe complication of cancer that adversely affects the course of the disease,
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …
[HTML][HTML] The high costs of low-grade inflammation: persistent fatigue as a consequence of reduced cellular-energy availability and non-adaptive energy expenditure
TE Lacourt, EG Vichaya, GS Chiu, R Dantzer… - Frontiers in behavioral …, 2018 - frontiersin.org
Chronic or persistent fatigue is a common, debilitating symptom of several diseases.
Persistent fatigue has been associated with low-grade inflammation in several models of …
Persistent fatigue has been associated with low-grade inflammation in several models of …
Disrupted skeletal muscle mitochondrial dynamics, mitophagy, and biogenesis during cancer cachexia: a role for inflammation
BN VanderVeen, DK Fix… - Oxidative medicine and …, 2017 - Wiley Online Library
Chronic inflammation is a hallmark of cancer cachexia in both patients and preclinical
models. Cachexia is prevalent in roughly 80% of cancer patients and accounts for up to 20 …
models. Cachexia is prevalent in roughly 80% of cancer patients and accounts for up to 20 …
Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis
F Pala, D Di Girolamo, S Mella, S Yennek… - Journal of cell …, 2018 - journals.biologists.com
During growth, homeostasis and regeneration, stem cells are exposed to different energy
demands. Here, we characterise the metabolic pathways that mediate the commitment and …
demands. Here, we characterise the metabolic pathways that mediate the commitment and …
The redox protein high-mobility group box 1 in cell death and cancer
Significance: As a redox-sensitive protein, high-mobility group box 1 (HMGB1) is implicated
in regulating stress responses to oxidative damage and cell death, which are closely related …
in regulating stress responses to oxidative damage and cell death, which are closely related …
New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets
Colorectal cancer (CRC), despite numerous therapeutic and screening attempts, still
remains a major life-threatening malignancy. CRC etiology entails both genetic and …
remains a major life-threatening malignancy. CRC etiology entails both genetic and …
Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia
S Chiappalupi, G Sorci, A Vukasinovic… - Journal of cachexia …, 2020 - Wiley Online Library
Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …