The maintenance of iron homeostasis is essential for proper cardiac function. A growing
body of evidence suggests that iron imbalance is the common denominator in many …

Introduction: Free radicals are reactive oxygen species that constantly circulate through the
body and occur as a side effect of many reactions that take place in the human body. Under …

The glutathione (GSH) system is considered to be one of the most powerful endogenous
antioxidant systems in the cardiovascular system due to its key contribution to detoxifying …

Cardiovascular diseases (CVDs) are the leading cause of death globally. An effective
strategy to mitigate the burden of CVDs has been to monitor patients' biomedical variables …

WNT signalling comprises a diverse spectrum of receptor-mediated pathways activated by a
large family of WNT ligands and influencing fundamental biological processes. WNT …

Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

Phenolic compounds are naturally present as secondary metabolites in plant‐based
sources such as fruits, vegetables, and spices. They have received considerable attention …

Abstract oxidative stress is caused by an abundant generation of reactive oxygen species,
associated to a diminished capacity of the endogenous systems of the organism to …

Caffeic acid (CA) and its phenethyl ester (CAPE) are naturally occurring hydroxycinnamic
acids with an interesting array of biological activities; eg, antioxidant, anti-inflammatory …

NADPH oxidase as an important source of intracellular reactive oxygen species (ROS) has
gained enormous importance over the years, and the detailed structures of all the …