An essential role for Hedgehog (Hh) signaling in human cancer has been established
beyond doubt. At present, targeting Hh signaling has mainly been investigated with SMO …

Hedgehog signaling pathway originally identified in the fruit fly Drosophila is an
evolutionarily conserved signaling mechanism with crucial roles in embryogenesis, growth …

Pathway analysis is often the first choice for studying the mechanisms underlying a
phenotype. However, conventional methods for pathway analysis do not take into account …

Prostate cancer (PCa) is the most diagnosed malignancy in the men worldwide. Cancer
stem cells (CSCs) are the sub-population of cells present in the tumor which possess unique …

Prostate cancer (PCa) represents a major cause of cancer mortality among men in
developed countries. Patients with recurrent disease initially respond to androgen …

Prostate cancer (PCA) is the leading malignancy in men and the second leading cause of
cancer-related deaths. Hypoxia (low O 2 condition) is considered an early event in prostate …

Cancer stem cells (CSCs) in prostate cancer (CaP) are regarded as major contributors to
radioresistance due to complex mechanisms including enhanced DNA repair, increased …

Advanced prostate cancer is a classic example of the intractability and consequent lethality
that characterizes metastatic carcinomas. Novel treatments have improved the survival of …

Prostate cancer (PCa) is the most frequently diagnosed cancer in men and the second most
common cause of cancer-related mortality among men in the developed world …

Benign prostatic hyperplasia (BPH) is a chronic proliferative disease showing stromal-
dominant proliferation. However, the detailed proliferation mechanism has remained …