ABSTRACT rRNAs are extensively modified during their transcription and subsequent
maturation in the nucleolus, nucleus and cytoplasm. RNA modifications, which are installed …

Cancer is one of the major diseases threatening human life and health worldwide.
Epigenetic modification refers to heritable changes in the genetic material without any …

Telomerase adds telomeric repeats at chromosome ends to compensate for the telomere
loss that is caused by incomplete genome end replication. In humans, telomerase is …

Nonsense mutations create premature termination codons (PTCs), activating the nonsense-
mediated mRNA decay (NMD) pathway to degrade most PTC-containing mRNAs. The …

During ribosome biogenesis, ribosomal RNAs acquire various chemical modifications that
ensure the fidelity of translation, and dysregulation of the modification processes can cause …

The enzyme telomerase adds telomeric repeats to chromosome ends to balance the loss of
telomeres during genome replication. Telomerase regulation has been implicated in cancer …

The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …

Developing methods for accurate detection of RNA modifications remains a major challenge
in epitranscriptomics. Next-generation sequencing-based mapping approaches have …

Chronic obstructive pulmonary disease and pulmonary fibrosis have been hypothesized to
represent premature aging phenotypes. At times, they cluster in families, but the genetic …

RNA methylations are essential both for RNA structure and function, and are introduced by a
number of distinct methyltransferases (MTases). In recent years, N 6-methyladenosine …