The complement cascade comprises soluble and cell surface proteins and is an important
arm of the innate immune system. Once activated, the complement system rapidly generates …

The complement system is recognised as a protector against blood-borne pathogens and a
controller of immune system and tissue homoeostasis. However, dysregulated complement …

The complement system is involved in the pathogenesis of several ocular diseases,
providing a rationale for the investigation of complement-targeting therapeutics for these …

ABSTRACT A refined understanding of the role of complement in the pathogenesis of
glomerular and other kidney diseases has, over the past two decades, been matched by the …

Introduction Complement 3 glomerulopathy (C3G) is a rare inflammatory kidney disease
mediated by dysregulation of the alternative complement pathway. No targeted therapy …

Novel agents for treating IgA nephropathy : Current Opinion in Nephrology and
Hypertension Novel agents for treating IgA nephropathy : Current Opinion in Nephrology …

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder affecting
approximately 1 in 20 000 people. While most patients with ITP are successfully managed …

IgA nephropathy (IgAN) is the most common glomerular disease worldwide, with an
estimated annual incidence of 25 per million adults. Despite optimized supportive care …

ABSTRACT Introduction IgA nephropathy (IgAN) is the commonest primary
glomerulonephritis worldwide and may progress to end-stage kidney disease (ESKD) within …

Historically, the complement system (classical, lectin, alternative, and terminal pathways) is
known to play a crucial role in the etiopathogenesis of many kidney diseases. Direct or …