[HTML][HTML] Microtubular dysfunction and male infertility

S Gunes, P Sengupta, R Henkel… - The world journal of …, 2020 - ncbi.nlm.nih.gov
Microtubules are the prime component of the cytoskeleton along with microfilaments. Being
vital for organelle transport and cellular divisions during spermatogenesis and sperm motility …

[HTML][HTML] Signaling pathways regulating blood–tissue barriers—Lesson from the testis

Q Wen, EI Tang, Y Gao, TT Jesus, DS Chu… - … Et Biophysica Acta (BBA …, 2018 - Elsevier
Signaling pathways that regulate blood–tissue barriers are important for studying the biology
of various blood–tissue barriers. This information, if deciphered and better understood, will …

[PDF][PDF] Dissecting mammalian spermatogenesis using spatial transcriptomics

H Chen, E Murray, A Sinha, A Laumas, J Li, D Lesman… - Cell reports, 2021 - cell.com
Single-cell RNA sequencing has revealed extensive molecular diversity in gene programs
governing mammalian spermatogenesis but fails to delineate their dynamics in the native …

Urban fine particulate matter exposure causes male reproductive injury through destroying blood-testis barrier (BTB) integrity

X Cao, L Shen, C Yan, Y Zhou, G Xiong, Y Wang, Y Liu… - Toxicology letters, 2017 - Elsevier
Blood-testis barrier (BTB) provides a suitable microenvironment for germ cells that is
required for spermatogenesis. Exposure to particulate matter (PM) is recognized to occasion …

Actin nucleator Spire 1 is a regulator of ectoplasmic specialization in the testis

Q Wen, N Li, X Xiao, W Lui, DS Chu, CKC Wong… - Cell Death & …, 2018 - nature.com
Germ cell differentiation during the epithelial cycle of spermatogenesis is accompanied by
extensive remodeling at the Sertoli cell–cell and Sertoli cell–spermatid interface to …

Defects of microtubule cytoskeletal organization in NOA human testes

X Wu, D Yun, M Sang, J Liu, L Zhou, J Shi… - Reproductive Biology …, 2022 - Springer
The importance of actin and microtubule (MT) cytoskeletons in testis function in rodents is
known to some extent, but its role in the etiology of azoospermia in humans remains …

Mechanistic insights into PFOS-mediated Sertoli cell injury

B Mao, D Mruk, Q Lian, R Ge, C Li, B Silvestrini… - Trends in molecular …, 2018 - cell.com
Studies have proven that per-and polyfluoroalkyl substances are harmful to humans, most
notably perfluorooctanesulfonate (PFOS). PFOS induces rapid disorganization of actin-and …

[HTML][HTML] F5-peptide induces aspermatogenesis by disrupting organization of actin-and microtubule-based cytoskeletons in the testis

Y Gao, DD Mruk, W Lui, WM Lee, CY Cheng - Oncotarget, 2016 - ncbi.nlm.nih.gov
During the release of sperm at spermiation, a biologically active F5-peptide, which can
disrupt the Sertoli cell tight junction (TJ) permeability barrier, is produced at the site of the …

[HTML][HTML] Regulation of the blood–testis barrier by a local axis in the testis: role of laminin α2 in the basement membrane

Y Gao, D Mruk, H Chen, WY Lui, WM Lee… - The FASEB …, 2017 - ncbi.nlm.nih.gov
Laminin α2 is one of the constituent components of the basement membrane (BM) in adult
rat testes. Earlier studies that used a mouse genetic model have shown that a deletion of …

Regulation of blood-testis barrier (BTB) dynamics, role of actin-, and microtubule-based cytoskeletons

Q Wen, EI Tang, N Li, DD Mruk, WM Lee… - Sertoli Cells: Methods …, 2018 - Springer
The blood-testis barrier (BTB) is an important ultrastructure in the testis that supports meiosis
and postmeiotic spermatid development since a delay in the establishment of a functional …