Targeting epigenetic dysregulation in autism spectrum disorders
ML Herrera, J Paraíso-Luna, I Bustos-Martínez… - Trends in Molecular …, 2024 - cell.com
Autism spectrum disorders (ASD) comprise a range of neurodevelopmental pathologies
characterized by deficits in social interaction and repetitive behaviors, collectively affecting …
characterized by deficits in social interaction and repetitive behaviors, collectively affecting …
[HTML][HTML] From compartments to loops: understanding the unique chromatin organization in neuronal cells
D Zagirova, A Kononkova, N Vaulin… - Epigenetics & Chromatin, 2024 - Springer
The three-dimensional organization of the genome plays a central role in the regulation of
cellular functions, particularly in the human brain. This review explores the intricacies of …
cellular functions, particularly in the human brain. This review explores the intricacies of …
Extensive long-range polycomb interactions and weak compartmentalization are hallmarks of human neuronal 3D genome
IA Pletenev, M Bazarevich, DR Zagirova… - Nucleic Acids …, 2024 - academic.oup.com
Chromatin architecture regulates gene expression and shapes cellular identity, particularly
in neuronal cells. Specifically, polycomb group (PcG) proteins enable establishment and …
in neuronal cells. Specifically, polycomb group (PcG) proteins enable establishment and …
Three-dimensional chromatin mapping of sensory neurons reveals that cohesin-dependent genomic domains are required for axonal regeneration
The in vivo three-dimensional genomic architecture of adult mature neurons at homeostasis
and after medically relevant perturbations such as axonal injury remains elusive. Here we …
and after medically relevant perturbations such as axonal injury remains elusive. Here we …
optimalTAD: annotation of topologically associating domains based on chromatin marks enrichment
In many eukaryotes, chromosomes are organized as strings of spatially segregated
Topologically Associating Domains (TADs), characterized by a substantially increased …
Topologically Associating Domains (TADs), characterized by a substantially increased …