Chagas disease is a vector-borne illness caused by the protozoan parasite Trypanosoma
cruzi (T. cruzi). It poses a significant public health burden, particularly in the poorest regions …

Introduction Chagas disease (CD) imposes social and economic burdens, yet the available
treatments have limited efficacy in the disease's chronic phase and cause serious adverse …

The conventional treatment of congenital toxoplasmosis is mainly based on the combination
of sulfadiazine and pyrimethamine. However, therapy with these drugs is associated with …

Trypanosomiases are a group of tropical diseases that have devastating health and socio-
economic effects worldwide. In humans, these diseases are caused by the pathogenic …

Chagas disease (CD) is a neglected protozoan infection caused by Trypanosoma cruzi,
which affects about 7 million people worldwide. There are two available drugs in …

The phytochemical investigation of Euphorbia desmondii resulted in the isolation of 15
previously undescribed triterpenoids (desmondiins A, CP) and 8 already described …

Background The discovery of artemisinin, an endoperoxide, encouraged the scientific
community to explore endoperoxides as potential anti-parasitic molecules. Although …

Chagas disease and leishmaniasis are both neglected tropical diseases that affect millions
of people around the world. Leishmaniasis is currently the second most widespread vector …

Introduction Chagas disease and toxoplasmosis caused by parasites Trypanosoma cruzi
and Toxoplasma gondii affect more than 28 million people in poor areas of Latin America …

Trypanosomiases are a group of tropical diseases that have devastating health and
socioeconomic effects worldwide. In humans, these diseases are caused by the pathogenic …