Drug-resistant epilepsy: multiple hypotheses, few answers
Epilepsy is a common neurological disorder that affects over 70 million people worldwide.
Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients …
Despite the recent introduction of new antiseizure drugs (ASDs), about one-third of patients …
Pharmacogenetics of direct oral anticoagulants: a systematic review
Dabigatran, rivaroxaban, apixaban, edoxaban, and betrixaban are direct oral anticoagulants
(DOACs). Their inter-individual variability in pharmacodynamics and pharmacokinetics …
(DOACs). Their inter-individual variability in pharmacodynamics and pharmacokinetics …
[HTML][HTML] Genetic determinants of response to clopidogrel and cardiovascular events
T Simon, C Verstuyft, M Mary-Krause… - New England journal …, 2009 - Mass Medical Soc
Background Pharmacogenetic determinants of the response of patients to clopidogrel
contribute to variability in the biologic antiplatelet activity of the drug. The effect of these …
contribute to variability in the biologic antiplatelet activity of the drug. The effect of these …
Very important pharmacogene summary
LM Hodges, SM Markova, LW Chinn… - Pharmacogenetics …, 2011 - journals.lww.com
ABCB1 (MDR1) is one of many ubiquitous adenosine triphosphate (ATP)-binding cassette
(ABC) genes present in all kingdoms of life that is responsible for cellular homeostasis [1–3] …
(ABC) genes present in all kingdoms of life that is responsible for cellular homeostasis [1–3] …
ABC multidrug transporters: structure, function and role in chemoresistance
FJ Sharom - Pharmacogenomics, 2008 - Taylor & Francis
Three ATP-binding cassette (ABC)-superfamily multidrug efflux pumps are known to be
responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 …
responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 …
Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature
ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1)
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …
is an adenosine triphosphate (ATP)-dependent efflux transporter located in the plasma …
Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition
SF Zhou - Xenobiotica, 2008 - Taylor & Francis
1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …
transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the …
A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function
KL Fung, MM Gottesman - Biochimica et Biophysica Acta (BBA)-Proteins …, 2009 - Elsevier
The MDR1 (ABCB1) gene encodes a membrane-bound transporter that actively effluxes a
wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant …
wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant …
Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a …
J Garcia-Donas, E Esteban, LJ Leandro-García… - The lancet …, 2011 - thelancet.com
Background Sunitinib is a tyrosine kinase inhibitor with proven efficacy in renal-cell
carcinoma, but some patients do not respond or need dose reductions due to toxicity …
carcinoma, but some patients do not respond or need dose reductions due to toxicity …
The clinical impact of pharmacogenetics on the treatment of epilepsy
W Löscher, U Klotz, F Zimprich, D Schmidt - Epilepsia, 2009 - Wiley Online Library
Drug treatment of epilepsy is characterized by unpredictability of efficacy, adverse drug
reactions, and optimal doses in individual patients, which, at least in part, is a consequence …
reactions, and optimal doses in individual patients, which, at least in part, is a consequence …