The molecular events causing memory loss and neuronal cell death in Alzheimer's disease
(AD) over time are still unknown. Here we found that picomolar concentrations of soluble …

The primary structure of canonical amyloid-β-protein was elucidated more than 30 years
ago, yet the forms of amyloid-β that play a role in Alzheimer's disease pathogenesis remain …

Intracellular neurofibrillary tangles (NFTs) composed of tau protein are a neuropathological
hallmark of several neurodegenerative diseases, the most common of which is Alzheimer's …

Epitope-specific enzymes are powerful tools for site-specific protein modification but
generally require genetic manipulation of the target protein. Here, we describe the …

Objective Oligomeric forms of amyloid β protein (oAβ) are believed to be principally
responsible for neurotoxicity in Alzheimer disease (AD), but it is not known whether anti‐Aβ …

Protein aggregation likely plays a key role in the initiation and spreading of Alzheimer's
disease pathology through the brain. Soluble aggregates of amyloid beta are believed to …

The accumulation of amyloid-β protein (Aβ) plays an early role in the pathogenesis of
Alzheimer's disease (AD). The precise mechanism of how Aβ accumulation leads to synaptic …

One of the hallmarks of Alzheimer's disease (AD) is structural cell damage and neuronal
death in the brains of affected individuals. As these changes are irreversible, it is important …

Passive immunotherapy RCTs failed to show clinically relevant effects in patients with
clinically manifest or prodromal dementia. The high incidence of ARIAs indicates that the risk …

The elimination of amyloid beta (Aβ) oligomers is a promising strategy for therapeutic drug
development of Alzheimer's disease (AD). AD mouse models that develop Aβ pathology …