Through advances in the past decades, the central role of aberrant protein aggregation has
been established in many neurodegenerative diseases. Crucially, however, the molecular …

The assembly of the β-amyloid peptide (Aβ) to form oligomers and fibrils is closely
associated with the pathogenesis and progression of Alzheimer's disease. Aβ is a shape …

In this work, early-stage Aβ42 aggregates were detected using a real-time fast amyloid
seeding and translocation (RT-FAST) assay. Specifically, Aβ42 monomers were incubated …

Microglia actively monitor the neighboring brain microenvironments and constantly contact
synapses with their unique ramified processes. In neurodegenerative diseases, including …

Neurodegenerative disorders emerge from the failure of intricate cellular mechanisms,
which ultimately lead to the loss of vulnerable neuronal populations. Research conducted …

Microglial cells are well known to be implicated in the pathogenesis of Alzheimer's disease
(AD), due to the impaired clearance of amyloid-β (Aβ) protein. In AD, Aβ accumulates in the …

Early cognitive impairment in Alzheimer's disease may result in part from synaptic
dysfunction caused by the accumulation oligomeric assemblies of amyloid β-protein (Aβ) …

Introduction It remains unclear why age increases risk of Alzheimer's disease and why some
people experience age‐related cognitive decline in the absence of dementia. Here we test …

Introduction Evidence strongly suggests that soluble oligomers of amyloid beta protein (oAβ)
help initiate the pathogenic cascade of Alzheimer's disease (AD). To date, there have been …

Despite ongoing debate, the amyloid β-protein (Aβ) remains the prime therapeutic target for
the treatment of Alzheimer's disease (AD). However, rational drug design has been …