Recent advancements toward therapeutic vaccines against Alzheimer's disease
K Herline, E Drummond, T Wisniewski - Expert Review of Vaccines, 2018 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is a devastating neurodegenerative disease
characterized by protein aggregates of amyloid β (Aβ) and tau. These proteins have normal …
characterized by protein aggregates of amyloid β (Aβ) and tau. These proteins have normal …
A review: Exploring the metabolic and structural characterisation of beta pleated amyloid fibril in human tissue using Raman spectrometry and SAXS
Amyloidosis is a deleterious condition caused by abnormal amyloid fibril build-up in living
tissues. To date, 42 proteins that are linked to amyloid fibrils have been discovered. Amyloid …
tissues. To date, 42 proteins that are linked to amyloid fibrils have been discovered. Amyloid …
Notch3ECD immunotherapy improves cerebrovascular responses in CADASIL mice
L Ghezali, C Capone, C Baron‐Menguy… - Annals of …, 2018 - Wiley Online Library
Objective CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy), caused by dominant mutations in the NOTCH3 receptor, is the most …
leukoencephalopathy), caused by dominant mutations in the NOTCH3 receptor, is the most …
Structural polymorphism and cytotoxicity of brain‐derived β‐amyloid extracts
To date, more than 37 amyloidogenic proteins have been found to form toxic aggregates that
are implicated in the progression of numerous debilitating protein misfolding diseases …
are implicated in the progression of numerous debilitating protein misfolding diseases …
A rationally designed humanized antibody selective for amyloid beta oligomers in Alzheimer's disease
E Gibbs, JM Silverman, B Zhao, X Peng, J Wang… - Scientific reports, 2019 - nature.com
Advances in the understanding of Alzheimer's disease (AD) suggest that pathogenesis is not
directly related to plaque burden, but rather to soluble toxic amyloid-beta oligomers (AßO) …
directly related to plaque burden, but rather to soluble toxic amyloid-beta oligomers (AßO) …
Toxic amyloid-β oligomers induced self-replication in astrocytes triggering neuronal injury
Background Soluble amyloid-β oligomer (AβO) induced deleterious cascades have recently
been considered to be the initiating pathologic agents of Alzheimer's disease (AD) …
been considered to be the initiating pathologic agents of Alzheimer's disease (AD) …
Antibodies Raised Against an Aβ Oligomer Mimic Recognize Pathological Features in Alzheimer's Disease and Associated Amyloid-Disease Brain Tissue
AG Kreutzer, CMT Parrocha… - ACS Central …, 2023 - ACS Publications
Antibodies that target the β-amyloid peptide (Aβ) and its associated assemblies are
important tools in Alzheimer's disease research and have emerged as promising …
important tools in Alzheimer's disease research and have emerged as promising …
Formation of amyloid loops in brain tissues is controlled by the flexibility of protofibril chains
Neurodegenerative diseases, such as Alzheimer's disease (AD), are associated with protein
misfolding and aggregation into amyloid fibrils. Increasing evidence suggests that soluble …
misfolding and aggregation into amyloid fibrils. Increasing evidence suggests that soluble …
Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer's disease brain extracts
A Sandberg, E Berenjeno-Correa… - Alzheimer's Research & …, 2022 - Springer
Abstract Background In Alzheimer's disease (AD), amyloid-β 1–42 (Aβ42) neurotoxicity
stems mostly from its soluble oligomeric aggregates. Studies of such aggregates have been …
stems mostly from its soluble oligomeric aggregates. Studies of such aggregates have been …
Ganglioside-enriched phospholipid vesicles induce cooperative Aβ oligomerization and membrane disruption
A major hallmark of Alzheimer's disease (AD) is the accumulation of extracellular
aggregates of amyloid-β (Aβ). Structural polymorphism observed among Aβ fibrils in AD …
aggregates of amyloid-β (Aβ). Structural polymorphism observed among Aβ fibrils in AD …