Tau is a microtubule stabilizing protein that forms abnormal aggregates in many
neurodegenerative disorders, including Alzheimer's disease. We have previously shown …

Cumulative evidence collected in recent decades suggests that lysosomal dysfunction
contributes to neurodegenerative diseases, especially if amyloid proteins are involved …

Introduction Hippocampal volume (HV) and cortical thickness are commonly used imaging
biomarkers in Alzheimer's disease (AD) trials, and may have utility as selection criteria for …

Recent studies have found that β-amyloid (Aβ) oligomers may play much more important
roles than amyloid plaques in the pathogenesis of Alzheimer's disease (AD). However, due …

Aggregation of Aβ peptides is a key contributor to the etiology of Alzheimer's disease. Being
intrinsically disordered, monomeric Aβ is susceptible to conformational excursions …

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Due to
the complexity of the disorder and the presence of the blood-brain barrier (BBB), its drug …

Amyloid-beta (Aβ) toxic oligomers are critical early players in the molecular pathology of
Alzheimer's disease (AD). We have developed a Soluble Oligomer Binding Assay (SOBA …

As the most common form of dementia in the world, Alzheimer9s disease (AD) is a
progressive neurological disorder marked by cognitive and behavioral impairment …

Synapse loss is associated with cognitive decline in Alzheimer's disease, and owing to their
plastic nature, synapses are an ideal target for therapeutic intervention. Oligomeric amyloid …

Objectives: Beta-amyloid (Aβ) peptides are most toxic to cells in oligomeric form. It is
commonly accepted that oligomers can form ion channels in cell membranes and allow …