Ribosomal protein S6 (RPS6) is a component of the 40S small ribosomal subunit and
participates in the control of mRNA translation. Additionally, phospho (p)-RPS6 has been …

Drug resistance represents the major reason of pharmacological treatment failure. It is
supported by a broad spectrum of mechanisms, whose molecular bases have been …

Background Protein kinase CK2 inhibition has long been considered as an attractive anti-
cancer strategy based on the following considerations: CK2 is a pro-survival kinase, it is …

CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …

Imatinib resistance has become a major clinical problem for chronic myeloid leukemia. The
aim of the present study was to investigate the involvement of MEG3, a lncRNA, in imatinib …

Casein kinase (CK) is a type of conserved serine/threonine protein kinase that
phosphorylates many important proteins in body. Researchers found that CK is involved in a …

CK2 is a constitutively active protein kinase that assuring a constant level of phosphorylation
to its numerous substrates supports many of the most important biological functions …

The development of selective inhibitors of protein kinases is challenging because of the
significant conservation of the ATP binding site. Here, we describe a new mechanism by …

Abstract Introduction Chronic Myeloid Leukemia (CML) is a hematological disease which is
characterized by the presence of BCR-ABL fusion protein. Imatinib (IMA), a tyrosine kinase …

Abstract Long non-coding RNAs (LncRNAs) are a category of non-coding RNAs (ncRNAs)
with a length of 200 nt–100 kb lacking a significant open reading frame. The study of …