Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

The extracellular matrix as a multitasking player in disease

AD Theocharis, D Manou, NK Karamanos - The FEBS journal, 2019 - Wiley Online Library
Extracellular matrices (ECM s) are highly specialized and dynamic three‐dimensional (3D)
scaffolds into which cells reside in tissues. ECM is composed of a variety of fibrillar …

[HTML][HTML] 3D printed silk-gelatin hydrogel scaffold with different porous structure and cell seeding strategy for cartilage regeneration

Q Li, S Xu, Q Feng, Q Dai, L Yao, Y Zhang, H Gao… - Bioactive materials, 2021 - Elsevier
Hydrogel scaffolds are attractive for tissue defect repair and reorganization because of their
human tissue-like characteristics. However, most hydrogels offer limited cell growth and …

Injectable drug delivery systems for osteoarthritis and rheumatoid arthritis

MC Bruno, MC Cristiano, C Celia, N d'Avanzo… - ACS …, 2022 - ACS Publications
Joint diseases are one of the most common causes of morbidity and disability worldwide.
The main diseases that affect joint cartilage are osteoarthritis and rheumatoid arthritis, which …

[HTML][HTML] Harnessing tissue-derived extracellular vesicles for osteoarthritis theranostics

B Yin, J Ni, CE Witherel, M Yang, JA Burdick, C Wen… - Theranostics, 2022 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is a prevalent chronic whole-joint disease characterized by low-grade
systemic inflammation, degeneration of joint-related tissues such as articular cartilage, and …

Smart biomaterials for articular cartilage repair and regeneration

Z Gu, J Wang, Y Fu, H Pan, H He… - Advanced Functional …, 2023 - Wiley Online Library
Articular cartilage defects bring about disability and worldwide socioeconomic loss,
therefore, articular cartilage repair and regeneration is recognized as a global issue …

Review of synthetic and hybrid scaffolds in cartilage tissue engineering

M Wasyłeczko, W Sikorska, A Chwojnowski - Membranes, 2020 - mdpi.com
Cartilage tissue is under extensive investigation in tissue engineering and regenerative
medicine studies because of its limited regenerative potential. Currently, many scaffolds are …

[HTML][HTML] 3D printed hydrogel for articular cartilage regeneration

X Yang, S Li, Y Ren, L Qiang, Y Liu, J Wang… - Composites Part B …, 2022 - Elsevier
Tissue engineering is a promising strategy for damaged cartilage tissue repair. Three-
dimensional (3D) printed hydrogel exhibits great potential in cartilage tissue engineering for …

Poly (vinyl alcohol)-based nanofibrous electrospun scaffolds for tissue engineering applications

MA Teixeira, MTP Amorim, HP Felgueiras - Polymers, 2019 - mdpi.com
Tissue engineering (TE) holds an enormous potential to develop functional scaffolds
resembling the structural organization of native tissues, to improve or replace biological …

[HTML][HTML] Small extracellular vesicles in combination with sleep-related circRNA3503: a targeted therapeutic agent with injectable thermosensitive hydrogel to prevent …

SC Tao, JY Huang, Y Gao, ZX Li, ZY Wei, H Dawes… - Bioactive materials, 2021 - Elsevier
Osteoarthritis (OA), characterized by chondrocyte apoptosis and disturbance of the balance
between catabolism and anabolism of the extracellular matrix (ECM), is the most common …