Regulation of MHC I molecules in glioblastoma cells and the sensitizing of NK cells

T Burster, F Gärtner, C Bulach, A Zhanapiya, A Gihring… - Pharmaceuticals, 2021 - mdpi.com
Immunotherapy has been established as an important area in the therapy of malignant
diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can …

Versatile hyperbranched poly (β-hydrazide ester) macromers as injectable antioxidative hydrogels

Q Xu, M Venet, W Wang, J Creagh-Flynn… - … applied materials & …, 2018 - ACS Publications
Synthetic reactive oxygen species (ROS)-responsive biomaterials have emerged as a useful
platform for regulating critical aspects of ROS-induced pathologies and can improve such …

Bioresponse inspired nanomaterials for targeted drug and gene delivery

S Sharma, MN Javed, FH Pottoo… - Pharmaceutical …, 2019 - ingentaconnect.com
The traditional drug delivery techniques are unresponsive to the altering metabolic states of
the body and fail to achieve target specific drug delivery, which results in toxic plasma …

A synthetic-biology-inspired therapeutic strategy for targeting and treating hepatogenous diabetes

S Xue, J Yin, J Shao, Y Yu, L Yang, Y Wang, M Xie… - Molecular Therapy, 2017 - cell.com
Hepatogenous diabetes is a complex disease that is typified by the simultaneous presence
of type 2 diabetes and many forms of liver disease. The chief pathogenic determinant in this …

Fab-conjugated PLGA nanoparticles effectively target cancer cells expressing human CD44v6

PJ Kennedy, F Sousa, D Ferreira, C Pereira, M Nestor… - Acta biomaterialia, 2018 - Elsevier
Targeting of CD44 isoforms containing exon v6 (CD44v6) represents a viable strategy for
the therapy and/or early diagnosis of metastatic cancers of the epithelium (eg gastric and …

Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal-Melphalan Prodrug for …

N Oddone, F Boury, E Garcion… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma (GBM) is the most frequent and aggressive primary tumor of the brain and
averages a life expectancy in diagnosed patients of only 15 months. Hence, more effective …

Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms

X Chen, S Lei, J Lin, P Huang - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
Introduction In recent years, to improve the precision of drug delivery and reduce toxicity
associated from the uncontrolled drug release at off-target locations, extensive efforts have …

Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance

S Fakhri, SZ Moradi, F Faraji, T Farhadi… - Cancer and Metastasis …, 2023 - Springer
The tumor microenvironment (TME) plays a pivotal role in cancer development and
progression. In this line, revealing the precise mechanisms of the TME and associated …

In Vivo Computing Strategies for Tumor Sensitization and Targeting

S Shi, Y Chen, X Yao - IEEE Transactions on Cybernetics, 2020 - ieeexplore.ieee.org
Several evolution strategies for in vivo computation are proposed with the aim of realizing
tumor sensitization and targeting (TST) by externally manipulable nanoswimmers. In such …

Nanomedicine for acute brain injuries: insight from decades of cancer nanomedicine

RM Kandell, LE Waggoner, EJ Kwon - Molecular pharmaceutics, 2020 - ACS Publications
Acute brain injuries such as traumatic brain injury and stroke affect 85 million people a year
worldwide, and many survivors suffer from long-term physical, cognitive, or psychosocial …