Regulation of MHC I molecules in glioblastoma cells and the sensitizing of NK cells
T Burster, F Gärtner, C Bulach, A Zhanapiya, A Gihring… - Pharmaceuticals, 2021 - mdpi.com
Immunotherapy has been established as an important area in the therapy of malignant
diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can …
diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can …
Versatile hyperbranched poly (β-hydrazide ester) macromers as injectable antioxidative hydrogels
Synthetic reactive oxygen species (ROS)-responsive biomaterials have emerged as a useful
platform for regulating critical aspects of ROS-induced pathologies and can improve such …
platform for regulating critical aspects of ROS-induced pathologies and can improve such …
Bioresponse inspired nanomaterials for targeted drug and gene delivery
The traditional drug delivery techniques are unresponsive to the altering metabolic states of
the body and fail to achieve target specific drug delivery, which results in toxic plasma …
the body and fail to achieve target specific drug delivery, which results in toxic plasma …
A synthetic-biology-inspired therapeutic strategy for targeting and treating hepatogenous diabetes
S Xue, J Yin, J Shao, Y Yu, L Yang, Y Wang, M Xie… - Molecular Therapy, 2017 - cell.com
Hepatogenous diabetes is a complex disease that is typified by the simultaneous presence
of type 2 diabetes and many forms of liver disease. The chief pathogenic determinant in this …
of type 2 diabetes and many forms of liver disease. The chief pathogenic determinant in this …
Fab-conjugated PLGA nanoparticles effectively target cancer cells expressing human CD44v6
Targeting of CD44 isoforms containing exon v6 (CD44v6) represents a viable strategy for
the therapy and/or early diagnosis of metastatic cancers of the epithelium (eg gastric and …
the therapy and/or early diagnosis of metastatic cancers of the epithelium (eg gastric and …
Synthesis, Characterization, and In Vitro Studies of an Reactive Oxygen Species (ROS)-Responsive Methoxy Polyethylene Glycol-Thioketal-Melphalan Prodrug for …
N Oddone, F Boury, E Garcion… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma (GBM) is the most frequent and aggressive primary tumor of the brain and
averages a life expectancy in diagnosed patients of only 15 months. Hence, more effective …
averages a life expectancy in diagnosed patients of only 15 months. Hence, more effective …
Stimuli-responsive image-guided nanocarriers as smart drug delivery platforms
Introduction In recent years, to improve the precision of drug delivery and reduce toxicity
associated from the uncontrolled drug release at off-target locations, extensive efforts have …
associated from the uncontrolled drug release at off-target locations, extensive efforts have …
Current advances in nanoformulations of therapeutic agents targeting tumor microenvironment to overcome drug resistance
The tumor microenvironment (TME) plays a pivotal role in cancer development and
progression. In this line, revealing the precise mechanisms of the TME and associated …
progression. In this line, revealing the precise mechanisms of the TME and associated …
In Vivo Computing Strategies for Tumor Sensitization and Targeting
S Shi, Y Chen, X Yao - IEEE Transactions on Cybernetics, 2020 - ieeexplore.ieee.org
Several evolution strategies for in vivo computation are proposed with the aim of realizing
tumor sensitization and targeting (TST) by externally manipulable nanoswimmers. In such …
tumor sensitization and targeting (TST) by externally manipulable nanoswimmers. In such …
Nanomedicine for acute brain injuries: insight from decades of cancer nanomedicine
Acute brain injuries such as traumatic brain injury and stroke affect 85 million people a year
worldwide, and many survivors suffer from long-term physical, cognitive, or psychosocial …
worldwide, and many survivors suffer from long-term physical, cognitive, or psychosocial …