[HTML][HTML] The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity
Co-inhibitory receptors are important regulators of T-cell function that define the balance
between tolerance and autoimmunity. The immune regulatory function of co-inhibitory …
between tolerance and autoimmunity. The immune regulatory function of co-inhibitory …
PD-1/PD-L and autoimmunity: a growing relationship
Abstract Programmed death 1 (PD-1) and its ligands, namely PD-L1 and PD-L2, are one of
the key factors responsible for inhibitory T cell signaling, mediating the mechanisms of …
the key factors responsible for inhibitory T cell signaling, mediating the mechanisms of …
PD-1 and PD-1 ligands: from discovery to clinical application
T Okazaki, T Honjo - International immunology, 2007 - academic.oup.com
Abstract Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the
CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein …
CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein …
The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection
The programmed cell death 1 (PD-1) surface receptor binds to two ligands, PD-L1 and PD-
L2. Studies have shown that PD-1–PD-L interactions control the induction and maintenance …
L2. Studies have shown that PD-1–PD-L interactions control the induction and maintenance …
Role of PD-1 in immunity and diseases
K Chamoto, M Al-Habsi, T Honjo - Emerging concepts targeting immune …, 2017 - Springer
Immunity developed to defend our bodies from foreign particles, including bacteria and
viruses. Although effector cells responsible for acquired immunity, mainly T cells, and B …
viruses. Although effector cells responsible for acquired immunity, mainly T cells, and B …
The role of the PD‐1 pathway in autoimmunity and peripheral tolerance
Programmed death‐1 (PD‐1) is a surface receptor critical for the regulation of T cell function
during immunity and tolerance. PD‐1 interactions with its ligands PD‐L1 and PD‐L2 inhibit T …
during immunity and tolerance. PD‐1 interactions with its ligands PD‐L1 and PD‐L2 inhibit T …
Recent insights into the role of the PD-1/PD-L1 pathway in immunological tolerance and autoimmunity
E Gianchecchi, DV Delfino, A Fierabracci - Autoimmunity reviews, 2013 - Elsevier
Autoimmune diseases represent a heterogeneous group of conditions whose incidence is
increasing worldwide. This has stimulated studies on their etiopathogenesis, derived from a …
increasing worldwide. This has stimulated studies on their etiopathogenesis, derived from a …
Role of PD-1 in regulating T-cell immunity
Abstract Programmed cell death-1 (PD-1) is a member of the CD28 superfamily that delivers
negative signals upon interaction with its two ligands, PD-L1 or PD-L2. PD-1 and its ligands …
negative signals upon interaction with its two ligands, PD-L1 or PD-L2. PD-1 and its ligands …
PD-1 and its ligands in T-cell immunity
ME Keir, LM Francisco, AH Sharpe - Current opinion in immunology, 2007 - Elsevier
The past year has seen significant advances in our understanding of the critical roles of
negative immunoregulatory signals delivered by the programmed death 1 (PD-1)–PD-1 …
negative immunoregulatory signals delivered by the programmed death 1 (PD-1)–PD-1 …
The programmed death 1/programmed death ligand 1 inhibitory pathway is up‐regulated in rheumatoid synovium and regulates peripheral T cell responses in human …
AP Raptopoulou, G Bertsias… - Arthritis & …, 2010 - Wiley Online Library
Objective T cells play a major role in the pathogenesis of rheumatoid arthritis (RA). The
programmed death 1 (PD‐1)/programmed death ligand 1 (PDL‐1) pathway is involved in …
programmed death 1 (PD‐1)/programmed death ligand 1 (PDL‐1) pathway is involved in …