IL-1 is an important mediator of inflammation and tissue damage in multiple organs, both in
experimental animal models of disease and in human diseases. The IL-1 family consists of …

The pathogenesis of inflammatory bowel disease (IBD) is only partially understood. Various
environmental and host (eg genetic-, epithelial-, immune and non-immune) factors are …

Abstract Nuclear Factor-κB (NF-κB) is a major transcription regulator of immune response,
apoptosis and cell-growth control genes, and is upregulated in inflammatory bowel disease …

Objective The aim of this study was to determine whether interleukin-1 alpha (IL1α),
interleukin-1 beta (IL1β), and IL1 receptor antagonist (IL1Ra) polymorphisms are implicated …

Genetic research has shaped the inflammatory bowel disease (IBD) landscape identifying
nearly two hundred risk loci. Nonetheless, the identified variants rendered only a partial …

The mechanisms responsible for development of inflammatory bowel disease (IBD) have not
been fully elucidated, although the main cause of disease pathology is attributed to up …

Background Ulcerative colitis (UC) is an inflammatory bowel disease of unknown etiology.
Among cytokines induced in UC, interleukin 1 antagonist (IL-1ra) and interleukin 1 β (IL-1β) …

Background NOD2/CARD15 was described as the first susceptibility gene to Crohn's
disease (CD). Polymorphisms in the TNFA gene and in the IL1 gene cluster, which are …

Association studies have identified the interleukin-1 receptor antagonist gene allele 2 (IL-
1RN* 2) as a marker of susceptibility in ulcerative colitis (UC). This study investigated the …

Background/aims: Extrahepatic biliary atresia remains one of the major hepatic causes of
death in early childhood. Though a number of hypotheses have been developed to account …