Amyotrophic lateral sclerosis

EL Feldman, SA Goutman, S Petri, L Mazzini… - The Lancet, 2022 - thelancet.com
Amyotrophic lateral sclerosis is a fatal CNS neurodegenerative disease. Despite intensive
research, current management of amyotrophic lateral sclerosis remains suboptimal from …

Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis

SA Goutman, O Hardiman, A Al-Chalabi… - The Lancet …, 2022 - thelancet.com
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease. The discovery of genes
associated with amyotrophic lateral sclerosis, commencing with SOD1 in 1993, started fairly …

Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis

SA Goutman, O Hardiman, A Al-Chalabi… - The Lancet …, 2022 - thelancet.com
The diagnosis of amyotrophic lateral sclerosis can be challenging due to its heterogeneity in
clinical presentation and overlap with other neurological disorders. Diagnosis early in the …

Reproducibility of EEG functional connectivity in Alzheimer's disease

CT Briels, DN Schoonhoven, CJ Stam… - Alzheimer's research & …, 2020 - Springer
Background Although numerous electroencephalogram (EEG) studies have described
differences in functional connectivity in Alzheimer's disease (AD) compared to healthy …

Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis

S Dukic, R McMackin, E Costello, M Metzger, T Buxo… - Brain, 2022 - academic.oup.com
Amyotrophic lateral sclerosis is a devastating disease characterized primarily by motor
system degeneration, with clinical evidence of cognitive and behavioural change in up to …

[HTML][HTML] Sleep research in 2020: COVID-19-related sleep disorders

M Partinen - The Lancet. Neurology, 2021 - ncbi.nlm.nih.gov
2020 has been an unprecedented year because a modified coronavirus, severe acute
respiratory syndrome corona virus 2 (SARS-CoV-2), spread rapidly from China to all …

Human brain connectivity: Clinical applications for clinical neurophysiology

M Hallett, W de Haan, G Deco, R Dengler… - Clinical …, 2020 - Elsevier
This manuscript is the second part of a two-part description of the current status of
understanding of the network function of the brain in health and disease. We start with the …

Pathological neural networks and artificial neural networks in ALS: diagnostic classification based on pathognomonic neuroimaging features

P Bede, A Murad, O Hardiman - Journal of neurology, 2021 - Springer
The description of group-level, genotype-and phenotype-associated imaging traits is
academically important, but the practical demands of clinical neurology centre on the …

Phenotypic categorisation of individual subjects with motor neuron disease based on radiological disease burden patterns: a machine-learning approach

P Bede, A Murad, J Lope, SLH Shing, E Finegan… - Journal of the …, 2022 - Elsevier
Motor neuron disease is an umbrella term encompassing a multitude of clinically
heterogeneous phenotypes. The early and accurate categorisation of patients is hugely …

Biomarkers in amyotrophic lateral sclerosis: current status and future prospects

R McMackin, P Bede, C Ingre, A Malaspina… - Nature Reviews …, 2023 - nature.com
Disease heterogeneity in amyotrophic lateral sclerosis poses a substantial challenge in drug
development. Categorization based on clinical features alone can help us predict the …