The pathophysiology after polytrauma represents a complex network of interactions. While it
was thought for a long time that the direct and indirect effects of hypoperfusion are most …

Recently, it has emerged that orthopaedic surgeons appear to be able to perform early
definitive management of major fractures more frequently than in the past. It has also been …

BACKGROUND Severe trauma is associated with massive alterations in metabolism. Thus
far, investigations have relied on traditional bioanalytic approaches including calorimetry or …

Purpose This study aimed to describe Stewart parameters in critically ill patients with an
apparently normal acid-base state and to determine the incidence of mixed metabolic acid …

PURPOSE: This study aimed to test the hypothesis that intensive care unit survivors and
nonsurvivors differ with regard to type and severity of acid-base disorders. MATERIALS AND …

Acidosis is an important cause of mortality in severe falciparum malaria. Lactic acid is a
major contributor to metabolic acidosis, but accounts for only one-quarter of the strong anion …

Lactic acidosis occurs when lactate production exceeds its metabolism. There are many
possible causes of lactic acidosis, and in any given patient, several causes may coexist. This …

A number of aromatic metabolites of tyrosine and phenylalanine have been investigated as
new perspective markers of infectious complications in the critically ill patients of intensive …

Hyperlactatemia is one of the most frequently encountered metabolic alterations in the
critically ill patient. Two important paradigms have framed current understanding of …

Background: Obesity is a risk factor for postinjury complications; in particular, obese patients
develop multiple organ failure (MOF) at a greater rate than do normal weight counterparts …