An insight into sustainable and green chemistry approaches for the synthesis of quinoline derivatives as anticancer agents
B Kumaraswamy, K Hemalatha, R Pal… - European Journal of …, 2024 - Elsevier
Quinolones, a key class of heterocyclics, are gaining popularity among organic and
medicinal chemists due to their promising properties. Quinoline, with its broad spectrum of …
medicinal chemists due to their promising properties. Quinoline, with its broad spectrum of …
Poly (ADP-ribose) polymerase (PARP) inhibitors as anticancer agents: An outlook on clinical progress, synthetic strategies, biological activity, and structure-activity …
Abstract Poly (ADP-ribose) polymerase (PARP) is considered an essential component in
case of DNA (Deoxyribonucleic acid) damage, response by sensing DNA damage and …
case of DNA (Deoxyribonucleic acid) damage, response by sensing DNA damage and …
Novel 4-(2-arylidenehydrazineyl) thienopyrimidine derivatives as anticancer EGFR inhibitors: Design, synthesis, biological evaluation, kinome selectivity and in silico …
HA Elsebaie, EA El-Bastawissy, KM Elberembally… - Bioorganic …, 2023 - Elsevier
The current study discovered fifteen new thieno [2, 3-d] pyrimidine derivatives with potential
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
anticancer action, including 5a-l, 6, and 7a-b. Results from the NCI screening revealed that …
Synthetic product-based approach toward potential antileishmanial drug development
Leishmaniasis is a parasitic disease and is categorized as a tropically neglected disease
(NTD) with no effective vaccines available. The available chemotherapeutics against …
(NTD) with no effective vaccines available. The available chemotherapeutics against …
Design, synthesis, and mechanistic insight of novel imidazolones as potential EGFR inhibitors and apoptosis inducers
FG Abdulrahman, HS Abulkhair, HS El Saeed… - Bioorganic …, 2024 - Elsevier
As regards to the structural analysis and optimization of diverse potential EGFR inhibitors,
two series of imidazolyl-2-cyanoprop-2-enimidothioates and ethyl …
two series of imidazolyl-2-cyanoprop-2-enimidothioates and ethyl …
[HTML][HTML] Recent Advances in Structural Optimization of Quinazoline-Based Protein Kinase Inhibitors for Cancer Therapy (2021–Present)
HT Abdel-Mohsen, MM Anwar, NS Ahmed… - Molecules, 2024 - mdpi.com
Cancer is a complicated, multifaceted disease that can impact any organ in the body.
Various chemotherapeutic agents have a low selectivity and are very toxic when used alone …
Various chemotherapeutic agents have a low selectivity and are very toxic when used alone …
Evaluation of Novel Spiro-pyrrolopyridazine Derivatives as Anticancer Compounds: In Vitro Selective Cytotoxicity, Induction of Apoptosis, EGFR Inhibitory Activity, and …
Cancer, characterized by uncontrolled cell proliferation, remains a global health challenge.
Despite advancements in cancer treatment, drug resistance and adverse effects on normal …
Despite advancements in cancer treatment, drug resistance and adverse effects on normal …
T6496 targeting EGFR mediated by T790M or C797S mutant: machine learning, virtual screening and bioactivity evaluation study
L Wang, D Fan, W Ruan, X Huang, W Zhu… - Journal of …, 2023 - Taylor & Francis
Acquired resistance to EGFR is a major impediment in lung cancer treatment, highlighting
the urgent need to discover novel compounds to overcome EGFR drug resistance. In this …
the urgent need to discover novel compounds to overcome EGFR drug resistance. In this …
New 8-Heterocyclic Xanthine Derivatives as Antiproliferative Agents: Synthesis and Biological Evaluation
BO Sucu - Journal of the Turkish Chemical Society Section A … - dergipark.org.tr
This research focuses on the synthesis, characterization, and evaluation of the anti-cancer
activity of novel 8-aryl substituted 1, 3-diethylxanthine derivatives. The anti-proliferative …
activity of novel 8-aryl substituted 1, 3-diethylxanthine derivatives. The anti-proliferative …