Background Alzheimer's disease (AD) is a neurodegenerative disorder and the predominant
type of dementia worldwide. It is characterized by the progressive and irreversible decline of …

The amyloid-β (Aβ) hypothesis was once believed to represent the pathogenic process of
Alzheimer's disease (AD). However, with the failure of clinical drug development and the …

Funding and financing for One Health initiatives at country level remain challenging as
investments commonly require demonstrated evidence of economic value or returns. The …

Probabilistic and parsimony-based arguments regarding available genetics data are used to
propose that Hardy and Higgin's amyloid cascade hypothesis is valid but is commonly …

Arterial spin labeling (ASL) perfusion MRI has been increasingly used in Alzheimer's
Disease (AD) research. However, ASL MRI sequences differ greatly in terms of arterial blood …

Background Alzheimer's disease (AD) is an aging-associated form of dementia
characterized by the pathological deposition of toxic misfolded proteins in the central …

Brain vascular health worsens with age, as is made evident by resting grey matter cerebral
blood flow (CBF GM) reductions and lengthening arterial transit time (ATT GM). Exercise …

ABSTRACT CBF measured with Arterial Spin Labeling (ASL) obtained by Magnetic
Resonance Imaging (MRI) may become an important biomarker by showing changes in …

Aging-related cognitive decline can be accelerated by a combination of genetic factors,
cardiovascular and cerebrovascular dysfunction, and amyloid-β burden. Whereas cerebral …

INTRODUCTION Cerebral blood flow (CBF) is reduced in cognitively impaired (CI)
Alzheimer's disease (AD) patients. We checked the sensitivity of timeencoded arterial spin …