Statins and epilepsy: preclinical studies, clinical trials and statin-anticonvulsant drug interactions

F Scicchitano, A Constanti, R Citraro… - Current drug …, 2015 - ingentaconnect.com
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) are potent
cholesterol-lowering drugs which also possess beneficial antioxidant, antiinflammatory …

Alterations of lipid metabolism in chronic nephropathies: mechanisms, diagnosis and treatment

A Lacquaniti, D Bolignano, V Donato, C Bono… - Kidney and Blood …, 2010 - karger.com
Nephropathic subjects show an increased tendency to develop cardiovascular diseases,
mainly as the consequence of several risk factors including increased oxidative stress …

Chronic obstructive pulmonary disease: patho-physiology, current methods of treatment and the potential for simvastatin in disease management

L Marin, P Colombo, M Bebawy… - Expert opinion on drug …, 2011 - Taylor & Francis
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a severe disease that leads
to a non-reversible obstruction of the small airways. The prevalence of this disease is rapidly …

The role of statins in chronic kidney disease

RG Kalaitzidis, MS Elisaf - American Journal of Nephrology, 2011 - karger.com
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality not only
amongst the general population, but also in patients with chronic kidney disease (CKD) …

Most appropriate animal models to study the efficacy of statins: a systematic review

V Pecoraro, L Moja, L Dall'Olmo… - European Journal of …, 2014 - Wiley Online Library
Background In animal models and clinical trials, statins are reported as effective in reducing
cholesterol levels and lowering the risk of cardiovascular diseases. We have aggregated the …

Effect of simvastatin on kidney function loss in patients with coronary heart disease: findings from the Scandinavian Simvastatin Survival Study (4S)

J Huskey, J Lindenfeld, T Cook, G Targher, J Kendrick… - Atherosclerosis, 2009 - Elsevier
OBJECTIVE: Statins have been hypothesized to slow loss of kidney function, however, data
is conflicting. This study assessed whether simvastatin reduces rates of kidney function loss …

The effects of statins on blood pressure in normotensive or hypertensive subjects—a meta-analysis of randomized controlled trials

M Banach, S Nikfar, R Rahimi… - International journal of …, 2013 - Elsevier
Objective The aim of this meta-analysis was to investigate whether statin therapy is
associated with blood pressure (BP)-lowering in patients with or without hypertension …

Use of statins for the treatment of spontaneous intracerebral hemorrhage: results of a pilot study

H Tapia-Perez, M Sanchez-Aguilar… - Central European …, 2009 - thieme-connect.com
Abstract Background and Study Aims: Spontaneous intracerebral hemorrhage (ICH)
represents the most fatal kind of stroke, and there is still no treatment available that improves …

Statin pleiotropy against renal injury

MS Kostapanos, EN Liberopoulos… - Journal of the …, 2009 - Wiley Online Library
Statins may exhibit significant renoprotective effects beyond their lipid‐lowering capacity.
Herein, the authors review data from human and animal models of renal disease as well as …

A reappraisal of the risks and benefits of treating to target with cholesterol lowering drugs

VM Alla, V Agrawal, A DeNazareth, S Mohiuddin… - Drugs, 2013 - Springer
Atherosclerotic cardiovascular disease (CVD) is the number one cause of death globally,
and lipid modification, particularly lowering of low density lipoprotein cholesterol (LDLc), is …